Lennart Heimer: concepts of the ventral striatum and extended amygdala.

Neurosurg Focus

Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

Published: September 2008

Dr. Lennart Heimer, the famous neuroanatomist of Swedish descent, died last year but left a legacy that will impact the neurosciences and potentially psychosurgery for years to come. He developed an anatomical technique for demonstrating the terminal boutons that helped to delineate basal forebrain anatomy. During these studies, he realized the relationship of basal forebrain structures to the limbic system, thus initiating the concept of the ventral striatum and parallel basal ganglia circuitry. Heimer excelled as a teacher as well and honed his brain dissection technique to one of the most effective tools for understanding neuroanatomy. His legendary sessions with neurosurgical residents resulted in his recognition as one of the world's leading fiber tract dissectors. His gentle, engaging manner has been documented in several media formats.

Download full-text PDF

Source
http://dx.doi.org/10.3171/FOC/2008/25/7/E8DOI Listing

Publication Analysis

Top Keywords

lennart heimer
8
ventral striatum
8
basal forebrain
8
heimer concepts
4
concepts ventral
4
striatum extended
4
extended amygdala
4
amygdala lennart
4
heimer famous
4
famous neuroanatomist
4

Similar Publications

In vivo parahippocampal white matter pathology as a biomarker of disease progression to Alzheimer's disease.

J Comp Neurol

December 2013

Department of Anatomy and Neurobiology, UC Irvine Medical School, Irvine, California, 92697-3940; Department of Neurology, UC Irvine Medical School, Irvine, California, 92697-3940.

Noninvasive diagnostic tests for Alzheimer's disease (AD) are limited. Postmortem diagnosis is based on density and distribution of neurofibrillary tangles (NFTs) and amyloid-rich neuritic plaques. In preclinical stages of AD, the cells of origin for the perforant pathway within the entorhinal cortex are among the first to display NFTs, indicating its compromise in early stages of AD.

View Article and Find Full Text PDF

The limbic lobe and its output channels: implications for emotional functions and adaptive behavior.

Neurosci Biobehav Rev

May 2006

Department of Neurosurgery and Neuroscience, University of Virginia, Box 800212, Charlottesville, VA 22908, USA.

Current dissatisfaction with the limbic system concept reflects a desire to move beyond the limbic system in efforts to explain key facets of emotional functions and motivational behavior. This review promotes an anatomical viewpoint, which originated as a result of histotechnical advances. These improvements paved the way for anatomical discoveries, which in turn led to the concepts of the ventral striatopallidal system and extended amygdala.

View Article and Find Full Text PDF

Instructional video. Dissection of the human brain.

Neurosurg Focus

June 2005

Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia 22908, USA.

View Article and Find Full Text PDF

A new anatomical framework for neuropsychiatric disorders and drug abuse.

Am J Psychiatry

October 2003

Department of Neurosurgery and Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.

Histotechnological breakthroughs in the late 1960s paved the way for anatomical discoveries that led to the concepts of the ventral striatal-pallidal system and the extended amygdala. These two macro-anatomical systems, together with the basal nucleus of Meynert, represent the main components of the new anatomy of the basal forebrain. The concept of the ventral striatal-pallidal system provided the first indication of the existence of parallel cortical-striatal-pallidal-thalamic-cortical circuits, which in turn led to the theory of segregated cortical-subcortical reentrant circuits as a conceptual framework for the study of neuropsychiatric disorders.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!