Objective: To investigate the effect of METH1 gene transfection on fibroblast proliferation and I, III collagen synthesis in rabbit ear scar.
Methods: The hypertrophic scar model on the rabbit ears was reproduced. 10 days after epithelization, Ad-METH1 was injected into the scar tissue. 30 days later, the effect of METH1 gene transfection on the angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue was detected by microcirculation microscope, AgNOR particle count and collagen dyeing.
Results: 30 days after injection of Ad-METH1, angiogenesis, fibroblast proliferation and the ratio of collagen I/III in the scar tissue were obviously suppressed.
Conclusion: Early application of Ad-METH1 after epithelization can markedly inhibit the formation of the hypertrophic scar.
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Adenovirus-mediated METH1 gene expression inhibits hypertrophic scarring in a rabbit ear model.
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View Article and Find Full Text PDF[Effect of METH1 gene transfection on the proliferation of rabbit's ear scar].
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Department of Plastic Surgery, Xijing Hospital, the Fourth Military Medical University. Xi'an 710032, China.
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