Objective: To study the antimutagenicity of Cordyceps taii polysaccharide (CDPl).
Methods: Ames test and micronucleus form assay of polychromatic erythrocytes in mice bone marrow were used to evaluate the antimutagenic effect of CDPI with different concentrations.
Results: CDP1 could inhibit the reverse mutation on Salmonella typhimuriun strains TA97, TA98, TA100 and TA102 without S9 in different degree, especially remarkable in the strains T97 ,T98 and T102. The maxium inhibition rates of strains TA97, TA98, TA100 and T102 were 68.5%, 79.5%,19. 8% and 81.3%, respectively. In addition, CDPI could significantly reduce micronucleus frequencies induced by cyclophosphamide, and the rate of maxium inhibition was 70.3%.
Conclusion: Cordyceps taii polysaccharide possesses significantly antimutagenic properties.
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BMC Complement Altern Med
August 2019
Zunyi Municipal Key Laboratory of Medicinal Biotechnology, Center for Translational Medicine, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563003, People's Republic of China.
Background: Hyperglycemia and dyslipidemia are classic features of patients with diabetes mellitus (DM). Cordyceps taii, a folk medicinal fungus native to southern China, possesses various pharmacological activities. This study aimed to assess the glucose-lowering and hypolipidemic effects of polysaccharides from C.
View Article and Find Full Text PDFExp Biol Med (Maywood)
January 2017
2 State Key Laboratory of Microbial Metabolism, and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, PR China.
The antibacterial agent helvolic acid, which was isolated from the active antitumor fraction of Cordyceps taii, showed potent cytotoxicity against different human cancer cells. In the present study, the in vivo antitumor effect of helvolic acid was investigated in murine sarcoma S180 tumor-bearing mice. Doses of 10 and 20 mg/kg/day helvolic acid did not exert significant antitumor activity.
View Article and Find Full Text PDFObjective: To seperate and identify the chemicals from the antitumor fraction of Cordyceps taii mycelia powder.
Methods: The mycelia of Cordyceps taii were prepared by the submerged fermentation technique. Chemical entities in the antitumor fraction of Cordyceps taii were isolated and purified by using different column chromatographies (silica gel, Sephadex LH-20 and MCI), and semi-preparative HPLC method.
BMC Complement Altern Med
August 2015
Guizhou Center for Translational Medicine & Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China.
BMC Complement Altern Med
July 2015
Guizhou Center for Translational Medicine & Laboratory of Cell Engineering, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China.
Background: Cordyceps taii, an entomogenous fungus native to south China, is a folk medicine with varieties of pharmacological activities including anticancer effect. To validate the ethnopharmacological claim against cancer, the antitumor and antimetastatic activities of chloroform extract of C. taii (CFCT) were investigated in vivo.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!