Benign intracranial hypertension (BICH) is characterized by elevated spinal fluid pressure in the absence of space-occupying lesion in the skull, dilated cerebral ventricles, significant neurological disorders, and altered spinal fluid composition. Forty-nine patients with a female predominance were examined. Their age ranged from 4 to 52 years (median 39 years). The most common predictors of BICH were overweight, endocrine disorders, and cerebral sinus thrombosis. Ophthalmoscopically, the patients were found to have early, moderate, and significant papilledema, and secondary optic atrophy. Examination of visual functions revealed these or those disturbances of visual acuity and/or field of vision in 43 of the 49 patients. The incidence and degree of visual disturbances depended on the stage of papilledema. Timely diagnosis and treatment in patients with BICH allows the development of visual disturbances to be prevented in them.
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Cancer Genet
January 2025
Cincinnati Children's Hospital Medical Center, Division of Oncology, Cincinnati, OH, USA; University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address:
Introduction: POT1 tumor predisposition (POT1-TPD) is an autosomal dominant disorder characterized by increased lifetime malignancy risk. Melanoma, angiosarcoma, and chronic lymphocytic leukemia are the most frequently reported malignancies [1]. Protection of telomeres protein 1 (POT1) is part of the shelterin protein complex to maintain/protect telomeres [2].
View Article and Find Full Text PDFJ Neurooncol
January 2025
University of Virginia, Charlottesville, VA, USA.
Background: Even a gross total resection of a benign epidermoid tumor (ET) carries a high risk of recurrence. The management strategy mostly involves redo surgical excision but at a significant cost of morbidity and mortality. The role of adjuvant radiation therapies in this scenario is still undefined.
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January 2025
Neurosurgery Division, Department of Surgery, Faculty of Medicine, Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Bali, Indonesia.
Neurenteric cysts, rare benign tumors, are most often found in the cervical or thoracic spinal cord, with intracranial occurrences being extremely uncommon. This case report describes a 52-year-old female with a neurenteric cyst in the cerebellopontine angle, presenting with headaches and balance disturbances. Magnetic resonance imaging (MRI) revealed a cystic lesion causing hydrocephalus, and surgical removal was performed using a retrosigmoid approach.
View Article and Find Full Text PDFCureus
December 2024
Department of Pediatrics, The Jikei University School of Medicine, Tokyo, JPN.
Congenital intracranial hemangiomas are rare benign vascular tumors that develop before birth. Although various treatments, including surgery, steroids, interferon-α, thalidomide, bevacizumab, or propranolol, have been reported, no standard therapy has been established. We report the case of a neonate with congenital intracranial hemangioma and central nervous system symptoms requiring therapeutic intervention.
View Article and Find Full Text PDFRadiol Case Rep
March 2025
Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morocco.
Inverted papilloma is a rare, benign epithelial tumor of the nasal and sinus cavities with an unclear etiology. It usually presents as unilateral nasal obstruction. Diagnosis is histological, and treatment is primarily surgical.
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