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Interclass Difference in Pneumonia Risk in COPD Patients Initiating Fixed Dose Inhaled Treatment Containing Extrafine Particle Beclometasone versus Fine Particle Fluticasone.
Int J Chron Obstruct Pulmon Dis
March 2022
Global Clinical Development, Chiesi Farmaceutici, S.p.A., Parma, Italy.
Background: Inhaled corticosteroids (ICS) afford therapeutic benefits in some COPD patients, but their widespread use is cautioned due to an increased risk of developing pneumonia. Subclass variations exist, and the risk profile differs for individual ICS. Formulation particle size has been identified as a potential effect modifier.
View Article and Find Full Text PDFDefinition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods.
Auto Immun Highlights
December 2017
Clinical Pathology Laboratory, 'S. Maria degli Angeli' Hospital, Pordenone, Italy.
Purpose: In the last two decades, thyroglobulin autoantibodies (TgAb) measurement has progressively switched from marker of thyroid autoimmunity to test associated with thyroglobulin (Tg) to verify the presence or absence of TgAb interference in the follow-up of patients with differentiated thyroid cancer. Of note, TgAb measurement is cumbersome: despite standardization against the International Reference Preparation MRC 65/93, several studies demonstrated high inter-method variability and wide variation in limits of detection and in reference intervals. Taking into account the above considerations, the main aim of the present study was the determination of TgAb upper reference limit (URL), according to the National Academy of Clinical Biochemistry guidelines, through the comparison of eleven commercial automated immunoassay platforms.
View Article and Find Full Text PDFDiagnostic value of the ISAC(®) allergy chip in detecting latex sensitizations.
Int Arch Occup Environ Health
May 2015
Department of Dermatology, Jena University Hospital, Erfurter Straße 35, 07740, Jena, Germany.
Purpose: Latex allergy can be diagnosed by different test methods such as IgE quantification, Western blot, cellular antigen stimulation test (CAST), and in vivo methods [e.g. skin prick test (SPT)].
View Article and Find Full Text PDFThe influence of carbohydrate structures present in common allergen sources on specific IgE results.
Eur Ann Allergy Clin Immunol
September 2007
Clinical Biochemistry Laboratory, Chubert Hospital, 56000 Vannes, France.
Background: Cross-reactive carbohydrate determinants (CCD) are well known interferants in specific IgE assays (sIgE). Glyco-epitopes are not restricted to CCD and extracts used to prepare in vitro tests contain many other glycoproteins able to bind glycan-specific IgE. The overall amounts of IgE-bindable glycan structures in allergen sources are unknown.
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