Disturbances of the oculomotor system are promising endophenotypes for schizophrenia. Increased error rates in the antisaccade task and prolonged antisaccade latencies have been found in patients with schizophrenia and their first degree relatives. We investigated oculomotor performance in 41 parents of schizophrenia patients and 22 controls with a prosaccade task and an antisaccade task. Parents were grouped into parents with a positive family history for schizophrenia (N=9) and parents with a negative family history for schizophrenia (N=32). An overlap-paradigm was applied; eye movements were recorded using infrared oculography. The combined group of parents made more antisaccade direction errors than controls (p=0.005) and there was a linear increase in direction errors from controls via negative family history parents to positive family history parents (p=0.008). Antisaccade latencies were prolonged in the combined parent group (p=0.057) compared to controls and there was a linear increase in latency with genetic loading (p=0.018). No group differences were found for prosaccade parameters. These results support the hypothesis that antisaccade impairment is associated with genetic loading for schizophrenia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpsychires.2008.05.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Using Community Composition and Successional Theory to Guide Site-Specific Coral Reef Management.
Glob Chang Biol
January 2025
Scripps Institution of Oceanography, UC San Diego, La Jolla, California, USA.
High spatial or temporal variability in community composition makes it challenging for natural resource managers to predict ecosystem trajectories at scales relevant to management. This is commonly the case in nearshore marine environments, where the frequency and intensity of disturbance events vary at the sub-kilometer to meter scale, creating a patchwork of successional stages within a single ecosystem. The successional stage of a community impacts its stability, recovery potential, and trajectory over time in predictable ways.
View Article and Find Full Text PDFObsessive-compulsive Symptoms Prevalence among Medical Students in Four Major Universities, Saudi Arabia: A Cross-Sectional Study.
Clin Pract Epidemiol Ment Health
December 2024
Department of Family and Community Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Background: Obsessive-compulsive disorder is recognized by the World Health Organization as one of the top 10 most disabling disorders globally. Characterized by recurrent and persistent thoughts (obsessions) and/or repetitive behaviors (compulsions), it significantly disrupts an individual's daily life, impacting routine, education, career development, and social relationships. The disorder's prevalence varies worldwide, with studies in Saudi Arabia showing a higher rate of obsessive-compulsive symptoms among medical students.
View Article and Find Full Text PDFManagement of Patients with Myocardial Injury After Noncardiac Surgery: A Retrospective Chart Review.
CJC Open
January 2025
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Background: Myocardial injury after noncardiac surgery (MINS) is associated with an increased incidence of cardiac morbidity and mortality. Little is known about how these patients are managed.
Methods: We performed a single-centre retrospective chart review of patients referred to a postoperative clinic with the diagnosis of MINS.
Pioneering Use of Extracorporeal Life Support in Intraoperative Cardiac Arrest in Dubai: A Case Report.
Cureus
December 2024
Department of Anaesthesia and Intensive Care, Latifa Hospital, Dubai Health, Dubai, ARE.
We describe, to our knowledge, the first use in Dubai of extracorporeal life support (ECLS) in a patient who suffered intraoperative cardiac arrest due to presumed cardiac channelopathy. A 40-year-old patient presented for open myomectomy surgery. She had no other medical problems apart from obesity.
View Article and Find Full Text PDFRacial Disparities in Time to Huntington Disease Diagnosis in North America: An ENROLL-HD Analysis.
Neurol Clin Pract
October 2024
Department of Neurology (AM, YB, SLP), David Geffen School of Medicine; Institute for Society and Genetics (AM); Interdepartmental Undergraduate Neuroscience Program (AM), UCLA; Division of General Internal Medicine (ACO), Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO; Department of Neurology (YB), Cedars Sinai Health Center, Los Angeles, CA; and Division of General Internal Medicine and Health Services Research (AB), Department of Medicine, David Geffen School of Medicine, UCLA.
Background And Objectives: There are well-documented racial and ethnic disparities in access to neurologic care and disease-specific outcomes. Although contemporary clinical and neurogenetic understanding of Huntington disease (HD) is thanks to a decades-long study of a Venezuelan cohort, there are a limited number of studies that have evaluated racial and ethnic disparities in HD. The goal of this study was to evaluate disparities in time from symptom onset to time of diagnosis of HD.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!