A group of dicyanodihydrofuran (DCDHF) fluorophores with thiol-reactive maleimide functionality has been synthesized. One of the methods involves aromatic nucleophilic substitution reaction between an arylfluoride containing DCDHF and an amine containing protected maleimide. An alternative and generally useful method involves combination of the Mitsunobu reaction of a DCDHF-OH with a furan or 2-methylfuran protected maleimide and then subsequent retro Diels-Alder reaction.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440721 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2006.07.142 | DOI Listing |
Publication Analysis
Top Keywords
dcdhf fluorophores
8
protected maleimide
8
improved synthesis
4
synthesis dcdhf
4
maleimide
4
fluorophores maleimide
4
maleimide functional
4
functional groups
4
groups group
4
group dicyanodihydrofuran
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!