This article presents an exemplar of a model-guided process evaluation that specifies the treatment model, assesses its implementation, monitors the fidelity of the model throughout the project, assesses model exposure and absorption, and helps understand the program's intermediate effects (proximal outcomes) as well as final effects (distal outcomes). The New Mexico study on office-based prescribing and community pharmacy dispensing of methadone is a research demonstration project that phases a small group of female methadone maintenance patients out of methadone clinics and into a program where they will obtain their scheduled doses of methadone at pharmacies that work in collaboration with physicians and a social worker.The patient's methadone treatment will in this way become part of their overall health care. Early detection of problems of implementation (e.g., the omission of program content or the delivery of inaccurate information) enables the researcher to make adjustments before the problems become unmanageable and the integrity of the original research design is compromised. A model-guided process evaluation can critically inform health services research demonstrations designed for enabling continuous, ongoing feedback and improvement of client-related services.
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http://dx.doi.org/10.1016/j.evalprogplan.2008.04.011 | DOI Listing |
Front Bioeng Biotechnol
December 2024
AO Vector-Best, Novosibirsk, Russia.
Introduction: Modification of natural enzymes to introduce new properties and enhance existing ones is a central challenge in bioengineering. This study is focused on the development of Taq polymerase mutants that show enhanced reverse transcriptase (RTase) activity while retaining other desirable properties such as fidelity, 5'- 3' exonuclease activity, effective deoxyuracyl incorporation, and tolerance to locked nucleic acid (LNA)-containing substrates. Our objective was to use AI-driven rational design combined with multiparametric wet-lab analysis to identify and validate Taq polymerase mutants with an optimal combination of these properties.
View Article and Find Full Text PDFInt J Comput Assist Radiol Surg
December 2024
IFCARS, Küssaberg, Germany.
Purpose: Based on CARS Congress events selected from its 40 year history, this editorial summarises the main challenges and solution concepts encountered, and what the future may hold for a model-centric world view in the specific domain of computer assisted radiology and surgery.
Methods: Altogether some 15,000 publications appeared in the CAR/CARS Congress Proceedings and Journal between 1985 and 2025, comprising approximately 3000 full papers and 12,000 long abstracts. Modelling occupied a central theme in many of these publications, particularly in the 2020s.
EMBO Rep
December 2024
Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, Santander, 39011, Spain.
The Retriever complex recycles a wide range of transmembrane proteins from endosomes to the plasma membrane. The cargo adapter protein SNX17 has been implicated in recruiting the Retriever complex to endosomal membranes, yet the details of this interaction have remained elusive. Through biophysical and structural model-guided mutagenesis studies with recombinant proteins and liposomes, we have gained a deeper understanding of this process.
View Article and Find Full Text PDFSci Rep
November 2024
Biostatistics and Research Methodology Unit, School of Medical Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia.
Int J Comput Assist Radiol Surg
October 2024
School of Medicine, Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Purpose: Model-Guided Medicine (MGM) is a transformative approach to health care that offers a comprehensive and integrative perspective that goes far beyond our current concepts. In this editorial, we want to take a closer look at this innovative concept and how health care could benefit from its further development and application.
Methods: The information presented here is primarily the opinion of the authors and is based on their knowledge in the fields of information technology, computer science, and medicine.
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