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Heparin-Induced Hemorrhagic Bullous Dermatosis: A Rare Complication of Unfractionated Heparin.
Cureus
July 2024
Thoracic and Vascular Surgery, Hôtel-Dieu de France, Beirut, LBN.
We present a case of an 82-year-old female with a significant medical history of hypertension and Alzheimer's disease who developed heparin-induced hemorrhagic bullous dermatosis during treatment for a subsegmental pulmonary embolism. The patient was admitted with lower extremity edema and cyanosis, diagnosed with a subsegmental pulmonary embolism, and started on therapeutic doses of unfractionated heparin. On the sixth day of heparin therapy, she developed abdominal bloating and a diffuse exanthematous rash, which progressed to hemorrhagic bullae on the plantar and dorsal aspects of her feet, alongside extensive purpura on her legs.
View Article and Find Full Text PDF[Methemoglobinemia].
Rev Med Interne
August 2024
Service de réanimation chirurgicale, CHU de Rouen, 76000 Rouen, France.
Methemoglobinemia (MetHb) refers to the state of oxidation of the iron ion "ferrous" (Fe to iron "ferric" (Fe) within the heme molecule that makes up hemoglobin (Hb). This state is physiological if its level remains controlled. The ferrous state of the heme molecule occurs in the event of significant oxidative stress.
View Article and Find Full Text PDFTrips Through the Skin: Reviewing Cutaneous Drug Reactions to Psychedelics and Hallucinogens.
Dermatitis
November 2024
Galaria Plastic Surgery & Dermatology, LLC, Chantilly, Virginia, USA.
Article Synopsis
- The review examines the dermatologic side effects of psychedelic and hallucinogenic substances, which are not well understood despite their therapeutic use.
- A comprehensive search of medical databases identified 22 studies linking these drugs to various skin reactions in 40 patients.
- Common skin reactions included hypersensitivity to cannabis, acneiform and urticarial eruptions from MDMA, and various reactions from ketamine and psilocybin, with most cases resolving after stopping the drug.
Acute Systemic Toxicity Caused by Topical Application of EMLA Cream on a Leg Ulcer: Case Report and Review of Literature.
Dermatol Ther (Heidelb)
April 2024
Department of Dermatology, Medical Center, University of Freiburg, Hauptstrasse 7, 79104, Freiburg, Germany.
Article Synopsis
- - EMLA cream, while generally safe, can lead to rare systemic toxicity, particularly in children or under specific conditions in adults, such as extensive application on damaged skin.
- - A case involving a 71-year-old man highlighted the risks; after applying EMLA for leg ulcers, he developed methemoglobinemia and showed severe symptoms like somnolence and cyanosis, with methemoglobin levels reaching 15.1%.
- - The patient's condition improved rapidly after the removal of the cream and oxygen treatment, underscoring that EMLA can be dangerous if not used carefully, even in older adults.
Methemoglobinemia.
J Educ Teach Emerg Med
October 2022
University of Toledo College of Medicine, Department of Emergency Medicine, Toledo, OH.
Audience: The targeted audience for this simulation are emergency medicine providers, including residents as well as advanced practice providers, to properly educate on recognizing, diagnosing, and managing methemoglobinemia.
Introduction: Methemoglobinemia is a blood disorder characterized by the presence of ferric form of hemoglobin in the blood. This form of hemoglobin can carry oxygen but is unable to release it effectively causing a range of symptoms including headache, dizziness, nausea, and cyanosis.
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