Purpose: To evaluate how well a head and neck immobilization device performed in reducing lumen morphology variability in repeated MR imaging of the carotid artery.
Materials And Methods: Quantitative measures of lumen and plaque characteristics may be important for longitudinal management of carotid atherosclerotic disease. However, quantitative measurements of the carotid artery are limited by their dependence on patient positioning, which can be quite variable. We created a head and neck immobilization device to reduce the variability of patient positioning during MR imaging of the carotid artery. In this article we describe the design and use of the immobilization device and assess how well its use reduced variability in vascular orientation and measurements of the carotid lumen cross-sectional area. Evaluation was based on 15 subjects who were repeatedly imaged without the immobilization device and 14 subjects who were repeatedly imaged with the device.
Results: Use of the immobilization device decreased the orientation variability from 9.1 degrees to 5.3 degrees (P = 0.0006) and the variability (defined as the standard deviation divided by the mean) of the cross-sectional area decreased from 0.24 to 0.18 (P = 0.04).
Conclusion: Using the immobilization device effectively reduces variability in repeated imaging of the carotid arteries.
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http://dx.doi.org/10.1002/jmri.21404 | DOI Listing |
Microbiol Spectr
January 2025
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Unlabelled: Group A (GAS) is a major human pathogen that causes several invasive diseases including necrotizing fasciitis. The host coagulation cascade initiates fibrin clots to sequester bacteria to prevent dissemination into deeper tissues. GAS, especially skin-tropic bacterial strains, utilize specific virulence factors, plasminogen binding M-protein (PAM) and streptokinase (SK), to manipulate hemostasis and activate plasminogen to cause fibrinolysis and fibrin clot escape.
View Article and Find Full Text PDFClin Ther
January 2025
Department of Mechanical, Energy and Materials Engineering, School of Industrial Engineering, University of Extremadura, Badajoz, Spain.
Purpose: The aim of this study was to propose a lateral oscillating device for the prevention of pressure ulcers by understanding the mechanisms of tissue protection in healthy individuals during prolonged decubitus. We also sought to determine the optimal time interval for oscillation, considering peak pressure peaks and tolerable pressure limits as a function of individual characteristics such as age, weight, height, gender, and BMI.
Methods: A quasi-experimental, descriptive and analytical observational study was conducted between January 2022 and June 2023 with a sample of 25 healthy volunteers.
Anal Chim Acta
February 2025
School of Life Sciences, The Second Affiliated Hospital, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, PR China. Electronic address:
Background: Glioma accounts for 80 % of all malignant primary brain tumors with a high mortality rate. Histopathological examination is the current diagnostic methods for glioma, but its invasive surgical interventions can cause cerebral edema or impair neural functioning. Liquid biopsy proves to be an efficient method for glioma detection.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Assessment of Movement Behaviours (AMBer), Leicester Lifestyle and Health Research Group, Diabetes Research Centre, University of Leicester, Leicester LE5 4PW, UK.
Background: Following shoulder surgery, controlled and protected mobilisation for an appropriate duration is crucial for appropriate recovery. However, methods for objective assessment of sling wear and use in everyday living are currently lacking. In this pilot study, we aim to determine if a sling-embedded triaxial accelerometer and/or wrist-worn sensor can be used to quantify arm posture during sling wear and adherence to sling wear.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Department of Physics, Yonsei University, Seoul 03722, Republic of Korea.
The rapid and reliable detection of pathogenic bacteria remains a significant challenge in clinical microbiology. Consequently, the demand for simple and rapid techniques, such as antimicrobial peptide (AMP)-based sensors, has recently increased as an alternative to traditional methods. Melittin, a broad-spectrum AMP, rapidly associates with the cell membranes of various gram-positive and gram-negative bacteria.
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