The brain proteome profile is highly conserved between Prnp-/- and Prnp+/+ mice.

Neuroreport

Laboratory of Molecular Neuropathology, Centre of Neuropathology and Prion Research, LAFUGA, Gene Centre, LMU, Munich, Germany.

Published: July 2008

The aim of this study is to compare the proteome of Prnp-/- (Zürich I) gene-ablated mouse brains with wild-type mouse brains. Fluorescence two-dimensional-difference gel electrophoresis (DIGE) and isotope-coded protein labeling (ICPL) were applied for brain homogenates. Similar quantitative protein profiles (

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Source
http://dx.doi.org/10.1097/WNR.0b013e3283046157DOI Listing

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