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Glioblastoma multiforme. | LitMetric

Glioblastoma multiforme.

Curr Treat Options Neurol

Herbert B. Newton, MD Dardinger Neuro-Oncology Center, Department of Neurology, Ohio State University Medical Center, 465 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA.

Published: July 2008

AI Article Synopsis

Article Abstract

Patients with newly diagnosed glioblastoma multiforme should undergo a maximal tumor resection and then, whenever possible, should be entered into a clinical trial. The current standard of care consists of external beam irradiation, to a total of 60 Gy over 6 weeks, in combination with low-dose daily temozolomide, followed by at least six cycles of adjuvant temozolomide. If radiotherapy and a temozolomide-based adjuvant regimen fail, the most active treatment approach appears to be bevacizumab and irinotecan. Molecular therapy, with drugs targeting growth factor receptors and critical signal transduction pathway mediators, is also under active investigation.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11940-008-0031-zDOI Listing

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