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distributed system estimates maintain approximately centralized control of smart urban drainage systems during communications outages.
Water Res X
January 2025
University of Michigan Civil and Environmental Engineering, 2350 Hayward St, Ann Arbor, 48104, Michigan, USA.
Real-time control of urban drainage systems (UDS) can reduce flood risk while enhancing water quality. However, internet-connected valves and weirs may become a liability during communications outages. Given that severe storms often cause both flooding and communications failures, it is critical that smart systems cope well with communications outages during these events.
View Article and Find Full Text PDFThe Stria Vascularis in Mice and Humans Is an Early Site of Age-Related Cochlear Degeneration, Macrophage Dysfunction, and Inflammation.
J Neurosci
July 2023
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425.
Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting communication and quality of life for millions of older adults. Multiple pathophysiologic manifestations, along with many cellular and molecular alterations, have been linked to presbyacusis; however, the initial events and causal factors have not been clearly established. Comparisons of the transcriptome in the lateral wall (LW) with other cochlear regions in a mouse model (of both sexes) of "normal" age-related hearing loss revealed that early pathophysiological alterations in the stria vascularis (SV) are associated with increased macrophage activation and a molecular signature indicative of inflammaging, a common form of immune dysfunction.
View Article and Find Full Text PDFThe imperfect storm: An uncommon presentation of Chagas disease.
Am J Emerg Med
November 2022
Department of Emergency Medicine, Medstar Georgetown University Hospital, United States of America. Electronic address:
Electrical storm is defined as three or more sustained episodes of ventricular tachycardia, ventricular fibrillation, or appropriate cardioverter-defibrillator shocks during a 24-h period. These patients are notoriously difficult to manage. We present a case secondary to Chagas disease that was responsive to lidocaine.
View Article and Find Full Text PDFIt has been recognized since comprehensive descriptions by Jean-Martin Charcot in 1868 and 1883 that development of what is usually known as neuropathic osteoarthropathy (or the Charcot foot) requires the coincidence of neuropathy and inflammation. Despite this, detailed understanding of the causes has remained remarkably limited in the succeeding century and a half. The aim of this descriptive account is to draw particular attention to the processes involved in both the onset and resolution of the inflammation that is an essential component of active disease.
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