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Perceived costs and benefits of companion dog keeping based on a convenience sample of dog owners.
Sci Rep
January 2025
Department of Ethology, ELTE Eötvös Loránd University, Budapest, Hungary.
The increasing trend of dog ownership is often linked to its perceived benefits for human physical and mental well-being. However, the psychological and practical demands of caring for a dog can significantly impact the owner's quality of life and the long-term success of the dog-owner relationship. This study aimed to provide a comprehensive overview of both the advantages and disadvantages of dog ownership, as perceived by a convenience sample of Hungarian dog owners (N = 246), who were assumed to be generally satisfied with their dogs.
View Article and Find Full Text PDFResearch Status of Clustered Regulary Interspaced Short Palindromic Repeats Technology in the Treatment of Human Papillomavirus (HPV) Infection Related Diseases.
Cancer Control
January 2025
Department of Haide College, Ocean University of China, Qingdao, China.
CRISPR/Cas9 technology has rapidly advanced as a pivotal tool in cancer research, particularly in the precision targeting required for both detecting and treating malignancies. Its high specificity and low off-target effects make it exceptionally effective in applications involving Human Papillomavirus (HPV) related diseases, most notably cervical cancer. This approach offers a refined methodology for the rapid detection of viral infections and provides a robust platform for the safe and effective treatment of diseases associated with viral infections through gene therapy.
View Article and Find Full Text PDFHarnessing antiviral RNAi therapeutics for pandemic viruses: SARS-CoV-2 and HIV.
Drug Deliv Transl Res
January 2025
The Kirby Institute, UNSW Sydney, Sydney, 2052, Australia.
Using the knowledge from decades of research into RNA-based therapies, the COVID-19 pandemic response saw the rapid design, testing and production of the first ever mRNA vaccines approved for human use in the clinic. This breakthrough has been a significant milestone for RNA therapeutics and vaccines, driving an exponential growth of research into the field. The development of novel RNA therapeutics targeting high-threat pathogens, that pose a substantial risk to global health, could transform the future of health delivery.
View Article and Find Full Text PDFDeciphering Pectin: A Comprehensive Overview of Its Origins, Processing, and Promising Utility.
ACS Omega
January 2025
Precision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, TERRA Teaching and Research Centre, Liège University, Passage des Déportés 2, Gembloux 4000, Belgium.
Pectin is an acidic heteropolysaccharide, a natural high molecular weight compound primarily found in higher plants. It consists of four major structural domains: homogalacturonan (HG), rhamnogalacturonan II (RG-II), rhamnogalacturonan I (RG-I), and xylogalacturonan (XGA). Various methods are currently employed for pectin extraction, including acid extraction, microbial fermentation, microwave-assisted extraction, and ion extraction, each with unique advantages and disadvantages.
View Article and Find Full Text PDFAspirin-free strategies after percutaneous coronary intervention: Old habits, consolidated evidence and future perspectives.
Eur J Intern Med
January 2025
Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
For almost two decades, dual antiplatelet therapy (DAPT) has been considered the cornerstone of pharmacological treatment in patients undergoing percutaneous coronary intervention (PCI). DAPT composition and duration have considerably evolved in the last decade moving from fixed treatment durations to tailored strategies based on the individual ischemic and bleeding risks. The increasing awareness of the prognostic relevance of bleeding events after PCI and the need for tailoring DAPT according to the individual bleeding and ischemic risks paved the way to newer DAPT modulation strategies by early aspirin withdrawal which have been shown to decrease bleeding without affecting therapeutic efficacy.
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