We report here the resection of a radiation-induced sarcoma (RIS) of the left clavicle developed in a 59-year-old woman 13 years after radiation for breast cancer. Surgery consisted of extirpation of the tumor with a combined resection of the total layer of the chest wall, the left brachiocephalic vein, and the left subclavian vein, reconstructed with a pediculated musculocutaneous graft using the right latissimus dorsi muscle. RIS of the clavicle is rare, and the prognosis might be poor. However, a complete removal of the tumor is feasible and can be performed safely.
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