A convenient gold(III)-catalyzed synthesis of azepines from the intermolecular annulation of propargyl esters and alpha,beta-unsaturated imines is reported (19 examples, 55-95% yield). This formal [4 + 3]-cycloaddition reaction is proposed to proceed via a stepwise process involving intramolecular trapping of an allyl-gold intermediate.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754784 | PMC |
| http://dx.doi.org/10.1021/ja803890t | DOI Listing |
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