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Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling.
J Inflamm (Lond)
November 2024
Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 10002, Taiwan.
Background: Polymorphonuclear neutrophils (PMN) activation by monosodium urate crystals (MSU) is crucial to acute gouty arthritis and subsequent spontaneous remission within 7-10 days. Activated PMNs release neutrophil extracellular traps (NETs) that entrap MSU crystals, forming NET-MSU aggregates. Whether NET-MSU aggregates contribute to the resolution of acute inflammation remains to be elucidated.
View Article and Find Full Text PDFNaringenin Suppresses the Hyperexcitability of Trigeminal Nociceptive Neurons Associated with Inflammatory Hyperalgesia: Replacement of NSAIDs with Phytochemicals.
Nutrients
November 2024
Laboratory of Food and Physiological Sciences, Department of Life and Food Sciences, School of Life and Environmental Sciences, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara 252-5201, Kanagawa, Japan.
Article Synopsis
- The study investigates the effects of naringenin (NRG) on inflammation-related hyperexcitability in the spinal trigeminal nucleus caudalis (SpVc), comparing its efficacy to diclofenac (DIC).
- Rats with induced inflammation in their whisker pads showed decreased pain thresholds, which normalized two days after treatment with NRG, DIC, or a combination of both.
- The results revealed that NRG, DIC, and the combined treatment significantly reduced the activity of SpVc neurons and their heightened sensitivity to mechanical stimuli in inflamed rats, suggesting NRG's potential for alleviating inflammatory pain.
A novel 3D cardiac microtissue model for investigation of cardiovascular complications in rheumatoid arthritis.
Stem Cell Res Ther
October 2024
Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland.
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects not only the joints but also has significant cardiovascular (CV) manifestations. The mechanistic interplay between RA and cardiovascular complications is not yet well understood due to the lack of relevant in vitro models. In this study, we established RA cardiac microtisses (cMTs) from iPSC-derived cardiomyocytes (CMs), endothelial cells (ECs) and cardiac fibroblasts (CFs) to investigate whether this fully human 3D multicellular system could serve as a platform to elucidate the connection between RA and CV disorders.
View Article and Find Full Text PDFProteomics Reveals Divergent Cardiac Inflammatory and Metabolic Responses After Inhalation of Ambient Particulate Matter With or Without Ozone.
Cardiovasc Toxicol
December 2024
Center for Public Health and Environmental Assessment, US Environmental Protection Agency, Durham, NC, 27711, USA.
Inhalation of ambient particulate matter (PM) and ozone (O) has been associated with increased cardiovascular morbidity and mortality. However, the interactive effects of PM and O on cardiac dysfunction and disease have not been thoroughly examined, especially at a proteomic level. The purpose of this study was to identify and compare proteome changes in spontaneously hypertensive (SH) rats co-exposed to concentrated ambient particulates (CAPs) and O, with a focus on investigating inflammatory and metabolic pathways, which are the two major ones implicated in the pathophysiology of cardiac dysfunction.
View Article and Find Full Text PDFAim: The objective of this study was to evaluate the potential of hydrogen in preventing and treating psychiatric symptoms, particularly depressed mood and loss of interest, and to explore its underlying mechanisms. A mouse model exhibiting inflammation-derived depressive symptoms was used for the investigation.
Methods: Institute of Cancer Research mice were subjected to a 7-day intervention of either 30% hydrogen or 40 g per day of air via jelly intake.
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