Esthesioneuroblastoma (ENB) is a rare malignant neoplasm arising from the olfactory neuroepithelium. ENB has no distinctive clinical picture, but often presents as chronic unilateral nasal obstruction or epistaxis. It has a long natural history; the 5-year survival rates have been estimated at 82%. A number of paraneoplastic syndromes have been described in the setting of ENB. Humoral hypercalcemia of malignancy (HHM) has never been described with ENB before. We describe a case of Kadish Stage C ENB with recurrent Hypercalcemia. The hypercalcemia became refractory to therapy and was the cause of death.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Diversity of Mycotoxins in Stored Paddy Rice: Contamination Patterns in the Mekong Delta, Vietnam.
Toxins (Basel)
December 2024
Mytox-South®, International Thematic Network, Ghent University, 9000 Ghent, Belgium.
Rice ( L.) is the most important food in Vietnam. However, rice is often lost in post-harvest due to fungal growth and mycotoxins contamination.
View Article and Find Full Text PDFNeratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial.
Clin Lung Cancer
December 2024
Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Medicine, Chicago, IL.
Background: Activating mutations in the epidermal growth factor receptor (EGFR) gene occur in 7% to 23% of patients with non-small-cell lung cancer (NSCLC). A small proportion of these (3-5%) are exon 18 mutations. Neratinib, an irreversible pan-HER tyrosine kinase inhibitor (TKI), had activity in the phase II SUMMIT basket study.
View Article and Find Full Text PDFPhase I study of BMS-986299, an NLRP3 agonist, as monotherapy and in combination with nivolumab and ipilimumab in patients with advanced solid tumors.
J Immunother Cancer
January 2025
Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.
Materials And Methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.
Synthesis of Branched Cyclo-Olefin Copolymers Using Neutral -Sulfonate--Diimine Nickel Catalyst.
Molecules
January 2025
School of Materials Science and Engineering, PCFM Lab, GD HPPC Lab, Sun Yat-sen University, Guangzhou 510275, China.
Article Synopsis
- The study focuses on the use of a neutral -sulfonate--diimine nickel catalyst for the homopolymerization of norbornene, yielding high-molecular-weight polynorbornene (PNB).
- The catalyst also facilitates the copolymerization of norbornene and ethylene, resulting in copolymers with low levels of norbornene.
- Microstructure analyses reveal that the resulting copolymers are branched cyclo-olefin copolymers (COCs) containing branched polyethylene units.
A phase I study of temsirolimus in combination with metformin in patients with advanced or recurrent endometrial cancer.
Gynecol Oncol
January 2025
Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Introduction: Molecular alterations in the PI3K/AKT and Ras/Raf/MEK/ERK pathways are frequently observed in patients with endometrial cancers. However, mTOR inhibitors, such as temsirolimus, have modest clinical benefits. In addition to inducing metabolic changes in cells, metformin activates AMPK, which in turn inhibits the mTOR pathway.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!