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UHRF1 Controls Thymocyte Fate Decisions through the Epigenetic Regulation of EGR1 Expression.
J Immunol
June 2020
Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
Thymocyte differentiation is a highly complex process that is accompanied by epigenetic changes. Ubiquitin-like containing PHD ring finger 1 (UHRF1) is a critical epigenetic modifier involved in various cellular processes. In this study, we demonstrated that it is highly expressed in T cell precursors of the thymus.
View Article and Find Full Text PDFMetabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells.
Sci Immunol
July 2018
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Article Synopsis
- The study investigates how extrinsic factors and intrinsic signal strength affect thymocyte (T cell precursor) development, focusing on the role of mTORC1 in this process.
- It reveals that mTORC1 interacts with metabolic programs to influence the development of two major T cell lineages, αβ and γδ T cells, by controlling metabolic processes like glycolysis and oxidative phosphorylation.
- The research identifies mTORC1’s role in regulating reactive oxygen species as a crucial factor in determining the developmental fate of thymocytes, linking T cell receptor and NOTCH signals to metabolic activity.
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