AI Article Synopsis
- Primary nasal-type natural killer/T-cell lymphoma of the testis is a rare cancer, with more cases typically arising from other sites.
- The study discusses a specific case and analyzes data from 16 other patients, noting these tumors are found in younger individuals and are linked to Epstein-Barr virus infections.
- The research highlights that these lymphomas aggressively progress and can show varying T-cell antigen expressions and potential genetic mutations.
Article Abstract
Primary nasal-type natural killer/T-cell lymphoma of the testis is a rare malignancy. Although dissemination to the testis from other sites occurs somewhat more frequently than a primary presentation, even secondary testicular involvement is uncommon. In this article, the authors report on the comprehensive histopathologic, immunohistochemical, and molecular analysis of a case of primary testicular nasal-type natural killer/T-cell lymphoma, and review the features of 16 previously reported patients. The investigation carried out in this study indicates that the testicular nasal-type natural killer/T-cell lymphomas occur at a younger age than their B-cell counterparts, express cytoplasmic CD3 and surface CD56, and consistently show an infection by Epstein-Barr virus. These tumors have variable expression of T-cell antigens other than cytoplasmic CD3 and may show monoclonal rearrangement of T-cell receptor genes. Testicular natural killer/T-cell lymphomas of nasal type invariably follow an aggressive clinical course.
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| http://dx.doi.org/10.1177/1066896907309687 | DOI Listing |
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