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[Analysis of fungal infections of external auditory canal and its risk factors in patients with chronic otitis media].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2025
The objective of this study is to analyze the detection rate, the pathogenic fungus distribution, risk factors and drug sensitivity of fungal infection of external auditory canal in patients diagnosed with chronic otitis media. The data of a total of 419 patients with chronic suppurative otitis media or middle ear cholesteatoma who were admitted from January 2019 to February 2023 were retrospectively analyzed. A total of 419 patients were included, and 71 patients（16.
View Article and Find Full Text PDFImpact of adaptation time on lincomycin removal in riverbank filtration: A long-term sand column study.
J Hazard Mater
December 2024
Center for Water and Ecology, State Key Joint Laboratory of Environment Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.
Riverbank filtration (RBF) is an effective pretreatment technology for drinking water, removing organic micropollutants (OMPs) mainly through biodegradation. Despite documented improvements in OMP removal with extended adaptation time, the mechanisms remain poorly understood. This study assessed the removal of 128 OMPs over 82 d in a simulated RBF system, identified those with improved removal, and analyzed their properties.
View Article and Find Full Text PDFSide effects associated with itraconazole therapy.
J Antimicrob Chemother
December 2024
Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, 4523 Clayton Ave, MSC 8051-0043-15, St. Louis, MO 63110, USA.
Background: Itraconazole is the treatment of choice for many fungal infections, including histoplasmosis. While the tolerability of itraconazole has been described in short-term trial settings, there are few studies on side effects during long-term therapy. Fluconazole, which is usually thought to be less toxic, is associated with 52% toxicity in long-term treatment.
View Article and Find Full Text PDFThe impact of fluconazole use on the fungal and bacterial microbiomes in recurrent Vulvovaginal Candidiasis (RVVC): a pilot study of vaginal and gastrointestinal site interplay.
Eur J Clin Microbiol Infect Dis
November 2024
School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia.
Purpose: Recurrent Vulvovaginal Candidiasis (RVVC) is a problematic clinical condition for which fluconazole treatment is commonly prescribed. This study investigated the interkingdom vaginal and gastrointestinal microbiomes of RVVC patients who use fluconazole intermittently or as longer-term maintenance therapy for symptom management and compared them to healthy controls.
Methods: Vaginal swabs and fecal samples were collected.
The antifungal protein NFAP2 has low potential to trigger resistance development in .
Microbiol Spectr
November 2024
Department of Biotechnology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Due to the increase in the number of drug-resistant strains, new antifungal compounds with limited potential for the development of resistance are urgently needed. NFAP2, an antifungal protein (AFP) secreted by () , is a promising candidate. We investigated the ability of to develop resistance to NFAP2 in a microevolution experiment compared with generic fluconazole (FLC).
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