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Potentiation of Tumor Hallmarks by the Loss of GULO, a Vitamin C Biosynthesis Gene in Humans.
Curr Mol Med
October 2024
Cancer and Translational Research Lab, Dr. D.Y. Patil Biotechnology & Bioinformatics Institute, Dr. D.Y. Patil Vidyapeeth, Pimpri. Pune, Maharashtra, 411033, India.
Vitamin C plays a significant role in various physiological functions. Humans depend on external sources of vitamin C due to the loss of the L-gulono-γ-lactone oxidase (GULO) gene that contributes to the synthesis of vitamin C. During the evolutionary loss of the GULO gene, physical, chemical, and biological factors were different from the present environmental settings.
View Article and Find Full Text PDFDeciphering defense system modulating bacteria-mobile genetic elements symbiosis in microbial aggregates under elevated hydraulic stress.
Water Res
January 2025
College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310085, China; Innovation Center of Yangtze River Delta, Zhejiang University, Jiashan 314100, China. Electronic address:
Article Synopsis
- Bacterial defense systems are evolving to protect against mobile genetic elements (MGEs), but their distribution in engineered systems like membrane bioreactors is not well understood.
- In this study, researchers found that bacterial defense systems in activated sludge flocs and membrane-attached biofilms showed similar patterns, influenced by genome size and bacterial type, particularly under stress.
- Additionally, while most defenses were similar between bacteria and their associated MGEs, a significant portion of viral elements carried unique defense systems that may enhance bacteria's ability to adapt to environmental challenges, especially regarding biotic defense and antibiotic resistance.
Phylogenetic Analysis of Pyruvate-Ferredoxin Oxidoreductase, a Redox Enzyme Involved in the Pharmacological Activation of Nitro-Based Prodrugs in Bacteria and Protozoa.
Biology (Basel)
March 2024
Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland.
The present frontrunners in the chemotherapy of infections caused by protozoa are nitro-based prodrugs that are selectively activated by PFOR-mediated redox reactions. This study seeks to analyze the distribution of PFOR in selected protozoa and bacteria by applying comparative genomics to test the hypothesis that PFOR in eukaryotes was acquired through horizontal gene transfer (HGT) from bacteria. Furthermore, to identify other putatively acquired genes, proteome-wide and gene enrichment analyses were used.
View Article and Find Full Text PDFBaculovirus entry into the central nervous system of caterpillars is independent of the viral protein tyrosine phosphatase.
Open Biol
February 2024
Laboratory of Virology, Wageningen University and Research, Droevendaalsesteeg 1, 6708 PB Wageningen, The Netherlands.
Neuroparasitism concerns the hostile take-over of a host's nervous system by a foreign invader, in order to alter the behaviour of the host in favour of the parasite. One of the most remarkable cases of parasite-induced host behavioural manipulation comprises the changes baculoviruses induce in their caterpillar hosts. Baculoviruses may manipulate caterpillar behaviour in two ways: hyperactivity (increased movement in the horizontal plane) and/or tree-top disease (movement to elevated levels in the vertical plane).
View Article and Find Full Text PDFUnique roles of adolescents' friends and fathers in predicting verbal aggression in future adult romantic relationships.
Dev Psychopathol
January 2024
University of Virginia, Charlottesville, VA, USA.
This 20-year prospective study examined verbal aggression and intense conflict within the family of origin and between adolescents and their close friends as predictors of future verbal aggression in adult romantic relationships. A diverse community sample of 154 individuals was assessed repeatedly from age 13 to 34 years using self-, parent, peer, and romantic partner reports. As hypothesized, verbal aggression in adult romantic relationships was best predicted by both paternal verbal aggression toward mothers and by intense conflict within adolescent close friendships, with each factor contributing unique variance to explaining adult romantic verbal aggression.
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