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Irisin reshapes bone metabolic homeostasis to delay age-related osteoporosis by regulating the multipotent differentiation of BMSCs via Wnt pathway.
Front Mol Biosci
January 2025
The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, China.
Introduction: Bone aging is linked to changes in the lineage differentiation of bone marrow stem cells (BMSCs), which show a heightened tendency to differentiate into adipocytes instead of osteoblasts. The therapeutic potential of irisin in addressing age-related diseases has garnered significant attention. More significantly, irisin has the capacity to enhance bone mass recovery and sustain overall bone health.
View Article and Find Full Text PDFXylaria iriomotensis sp. nov. from termite nests and notes on X. angulosa.
Bot Stud
January 2025
Department of Chemical Engineering and Biotechnology, Tatung University, Taipei, 10491, Taiwan.
Background: Fungus gardens of the termite Odontotermes formosanus, excavated from Iriomote Island, Okinawa Prefecture, Japan, were subsequently incubated under laboratory conditions. A Xylaria species emerging from these fungus gardens was initially identified as X. angulosa, a species originally described from North Sulawesi, Indonesia.
View Article and Find Full Text PDFUnloading damage evolution and rockburst risk assessment of Xuefengshan No.1 tunnel by combining multiple approaches.
Sci Rep
January 2025
College of Transportation Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Large-scale rock burst disasters often occur in high-stress and deep-buried tunnels, due to challenges in accurate forecasting and the lack of clarity regarding the underlying mechanisms largely. This study combined on-site stress drilling tests, coupled finite and discrete element simulations, and theoretical calculations to examine unloading damage, rockburst evolution, and deformation failure of the high-stress and deep-buried Xuefengshan No.1 tunnel.
View Article and Find Full Text PDFThe Potential Mechanism of Fructus Against Hyperuricemia: An Integration of Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments.
Nutrients
December 2024
Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
: Fructus (AOF) is a medicinal and edible resource that holds potential to ameliorate hyperuricemia (HUA), yet its mechanism of action warrants further investigation. : We performed network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments to investigate the potential action and mechanism of AOF against HUA. : The results indicate that 48 potential anti-HUA targets for 4 components derived from AOF were excavated and predicted through public databases.
View Article and Find Full Text PDFJoint response of surface subsidence and strong mine earthquake under high-positioned and thick-hard strata in deep coal mine.
Sci Rep
January 2025
College of Energy and Mining Engineering, Shandong University of Science and Technology, Qingdao, 266590, China.
Multiple active mining faces and extensive excavations under thick-hard strata in deep coal mines result in frequent strong mine earthquakes, often accompanied by significant surface subsidence deformation. Understanding the specific law of surface movement and the spatiotemporal distribution response to intense mine earthquakes is crucial for effectively preventing and mitigating dynamic disasters in deep mines. Utilizing the key layer theory, the intricate strata of the Yingpanhao Coal Mine are systematically delineated, drawing upon the engineering context of working faces 2201 and 2202 within the Ordos Chemical Co.
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