The margination dynamics of microparticles with different shapes has been analyzed within a laminar flow mimicking the hydrodynamic conditions in the microcirculation. Silica spherical particles, quasi-hemispherical and discoidal silicon particles have been perfused in a parallel plate flow chamber. The effect of the shape and density on their margination propensity has been investigated at different physiologically relevant shear rates S. Simple scaling laws have been derived showing that the number n of marginating particles scales as S(-0.63) for the spheres; S(-0.85) for discoidal and S(-1) for quasi-hemispherical particles, regardless of their density and size. Within the range considered for the shear rate, discoidal particles marginate in a larger number compared to quasi-hemispherical and spherical particles. These results may be of interest in drug delivery and bio-imaging applications, where particles are expected to drift towards and interact with the walls of the blood vessels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jbiomech.2008.03.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics.
Eur J Pharm Sci
July 2023
Genentech, Inc., South San Francisco, CA 94080, United States. Electronic address:
XmAb24306 is a lymphoproliferative interleukin (IL)-15/IL-15 receptor α (IL-15Rα) Fc-fusion protein currently under clinical investigation as an immunotherapeutic agent for cancer treatment. XmAb24306 contains mutations in IL-15 that attenuate its affinity to the heterodimeric IL-15 receptor βγ (IL-15R). We observe substantially prolonged pharmacokinetics (PK) (half-life ∼ 2.
View Article and Find Full Text PDFQuantifying Shear-induced Margination and Adhesion of Platelets in Microvascular Blood Flow.
J Mol Biol
January 2023
State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China; Department of Engineering Mechanics, Zhejiang University, Hangzhou, China. Electronic address:
Platelet margination and adhesion are two critical and closely related steps in thrombus formation. Using dissipative particle dynamics (DPD) method that seamlessly models blood cells, blood plasma, and vessel walls with functionalized surfaces, we quantify the shear-induced margination and adhesion of platelets in microvascular blood flow. The results show that the occurrence of shear-induced RBC-platelet collisions has a remarkable influence on the degree of platelet margination.
View Article and Find Full Text PDFChemical Structure and Shape Enhance MR Imaging-Guided X-ray Therapy Following Marginative Delivery.
ACS Appl Mater Interfaces
March 2022
Department of Chemistry, National Cheng Kung University, Tainan 701 Taiwan.
Ineffective site-specific delivery has seriously impeded the efficacy of nanoparticle-based drugs to a disease site. Here, we report the preparation of three different shapes (sphere, scroll, and oblate) to systematically evaluate the impact of the marginative delivery on the efficacy of magnetic resonance (MR) imaging-guided X-ray irradiation at a low dose of 1 Gy. In addition to the shape effect, the therapeutic efficacy is investigated for the first time to be strongly related to the structure effect that is associated with the chemical activity.
View Article and Find Full Text PDFintravital imaging in animal models in the lung remains challenging owing to respiratory motion artifacts. Here we describe a novel intravital imaging approach based on the computer-vision stabilization algorithm, Computer-Vision Stabilized Intravital Imaging. This method corrects lung movements and deformations at submicron precision in respiring mouse lungs.
View Article and Find Full Text PDFShear-induced gradient diffusivity of a red blood cell suspension: effects of cell dynamics from tumbling to tank-treading.
Soft Matter
September 2021
Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Hydrodynamic interactions generate a diffusive motion in particulates in a shear flow, which plays seminal roles in overall particulate rheology and its microstructure. Here we investigate the shear induced diffusion in a red-blood cell (RBC) suspension using a numerical simulation resolving individual motion and deformation of RBCs. The non-spherical resting shape of RBCs gives rise to qualitatively different regimes of cell dynamics in a shear flow such as tank-treading, breathing, tumbling and swinging, depending on the cell flexibility determined by the elastic capillary number.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!