AI Article Synopsis
- VKH disease is an autoimmune inflammatory condition related to the eyes, commonly associated with the HLA-DR4 and -DR1 genes in Mestizo populations.
- Researchers analyzed KIR receptor genes and HLA class I ligands in VKH patients versus controls, observing a trend towards increased group B KIR haplogroups and more activating KIR genes among patients.
- Although the study showed a greater prevalence of certain KIR-HLA combinations in VKH patients compared to controls, most differences lacked statistical significance, aligning with patterns seen in other autoimmune diseases.
Article Abstract
Vogt-Koyanagi-Harada (VKH) disease is a putative autoimmune ocular inflammatory disease and is known to be associated with HLA-DR4 and -DR1 in Mestizos. We examined the genes encoding KIR receptors and human leukocyte antigen (HLA) class I ligands in patients with VKH disease and compared to published controls. We found trends toward more group B KIR haplogroups (p=0.059), with more activating KIR genes, in patients compared to controls. All putative activating KIR-HLA combinations were more common in patients, and some inhibitory KIR-HLA combinations were more common in controls, although the differences were not statistically significant. The trends observed in this study are consistent with those reported for other autoimmune diseases.
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| http://dx.doi.org/10.1016/j.humimm.2008.04.005 | DOI Listing |
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