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Digital Papillary Adenocarcinoma at the Site of 5 Years of Recurrent Paronychia: Case Report and Literature Review.

Case Rep Oncol Med

December 2024

Hand and Upper Extremity Surgery, Barrington Orthopedic Specialists, Schaumburg, Illinois, USA.

Article Synopsis
  • Digital papillary adenocarcinoma (DPA) is a rare and often misdiagnosed malignant tumor, commonly mistaken for benign conditions, leading to delayed diagnosis and treatment.
  • A 57-year-old man with recurrent finger infections was ultimately diagnosed with DPA after a surgical evaluation and biopsy revealed both infection and the tumor, necessitating surgical removal.
  • Accurate diagnosis is vital due to the tumor's tendency for recurrence and metastasis, particularly to the lungs and lymph nodes, and current treatment primarily involves surgical excision with focus on achieving negative margins.
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Lung cancer is commonly diagnosed at advanced stages, often presenting with metastases. Although bone metastases are common in lung cancer patients, acrometastases - metastatic lesions in the bones of the hand - are exceedingly rare. Herein, we report the case of a 71-year-old male with previously undiagnosed lung adenocarcinoma, which first manifested as a painful swelling in the right hand.

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(Tricho-rhino-phalangeal syndrome 1) is a GATA transcriptional activator gene encoding for a protein used as a sensitive immunohistochemical marker of breast carcinomas. In dermatopathology, TRPS1 is used as a marker of mammary and extramammary Paget's disease and is also expressed by a variety of primary cutaneous tumors, mostly of adnexal origin. So far, very limited data exist on the expression of TRPS1 in metastatic skin tumors.

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Rare phalanges soft tissue and bony metastasis in vulvar squamous cell carcinoma: Case report.

Gynecol Oncol Rep

August 2024

Gynecol. Oncol., Department of Obstetrics and Gynecology, Charleston Area Medical Center, Charleston, WV, United States.

Article Synopsis
  • * When vulvar cancer spreads beyond the pelvis (metastatic vulvar cancer), it's uncommon and generally has a poor outlook for patients.
  • * This article discusses a unique case of recurrent vulvar squamous cell carcinoma that has metastasized to bones, soft tissue, lungs, clavicle, and even the brain.
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Introduction And Importance: Hand metastases are notably rare, comprising around 0.1% of all metastatic diseases, mainly originating from lung cancer, which is responsible for 30-40% of such cases. This report highlights a rare occurrence of distal phalangeal metastasis in a patient with Lynch syndrome, underscoring the diagnostic challenges associated with hand metastases.

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