Synthesis and biological activity of mustard derivatives of thymine.

Nucleosides Nucleotides Nucleic Acids

Laboratoire de Chimie des Substances Naturelles, Faculte des Sciences et Techniques Limoges, Universite de Limoges, France.

Published: May 2008

The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.

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http://dx.doi.org/10.1080/15257770802086872DOI Listing

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