Aim: To analyze the clinical features and risk factors of adverse reactions associated with telbivudine.
Methods: Clinical data were collected from cases that presented with serious adverse reactions to telbivudine. We analyzed general information and medicine status, clinical features, results of examination, and misdiagnosis.
Results: Out of 105 patients who were treated with telbivudine for hepatitis B in an outpatient department from January, 2007 to January, 2008, five presented with serious adverse drug reactions. Most of these five patients had used other nucleoside analogues in the past. Four were treated with a combination of telbivudine and interferon or another nucleoside analogue, while the other received an increased dose of telbivudine. The main adverse reactions were myalgia and general weakness. This was accompanied by cardiac arrhythmia in one patient, and nervous symptoms in three. Serum creatine kinase was elevated. The rate of misdiagnosis was high.
Conclusion: The adverse reactions were related to telbivudine, but the biological mechanism of the reactions is not yet clear. Combination therapy with interferon or another nucleoside analogue and a high dose may increase the risk of adverse reactions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716619 | PMC |
| http://dx.doi.org/10.3748/wjg.14.3549 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Working with technical purity: simulation of red tattoo pigment metabolism by online-liquid chromatography-electrochemistry-mass spectrometry.
Anal Bioanal Chem
January 2025
Institute of Inorganic and Analytical Chemistry, University of Münster, Münster, Germany.
Tattooing is a popular form of body art that has evolved from ancient times into being part of modern society. The understanding of biotransformation processes of coloring tattoo pigments in human skin is limited although skin reactions to tattoos with unknown culprits occur. Electrochemistry coupled to mass spectrometry (EC-MS) has widely been used as a tool for a purely instrumental approach to simulating the enzymatic biotransformation of xenobiotics.
View Article and Find Full Text PDFEfficacy of methylprednisolone pulse therapy in Chinese children with IgA vasculitis-associated nephritis (IgAVN).
J Nephrol
January 2025
Department of Pediatrics, Clinical Center of Pediatric Nephrology of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Background: One of the most common secondary glomerular diseases in children is IgA vasculitis-associated nephritis (IgAVN). Determining the best treatment for IgAVN based on current guidelines is controversial. The purpose of this study was to evaluate the efficacy of methylprednisolone pulse therapy in Chinese children with moderate and severe IgAVN.
View Article and Find Full Text PDFThe behavioral characteristics of addiction and mental disorder caused by dextromethorphan abuse were analyzed in multiple dimensions.
Expert Opin Drug Saf
January 2025
Shenzhen Institute of Pharmacovigilance and Risk Management, Shenzhen, Guangdong, China.
Background: The aims of this study were to promote the rational use and supervision of dextromethorphan (DM). This study analyzed serious adverse events such as addiction and mental disorders caused by DM in Shenzhen and the behavioral characteristics of people suspected of abusing DM on the Internet.
Methods: Adverse drug reaction/event (ADR/E) reports from 2017 to 2023 were extracted from the National Pharmaceutical Adverse Reaction Monitoring System database.
Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials.
Reg Anesth Pain Med
January 2025
Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
Background/importance: Opioids continue to play a key role in managing acute postoperative pain, but their use contributes to adverse outcomes. Buprenorphine may offer effective analgesia with a superior safety profile.
Objective: To compare the efficacy and safety of buprenorphine with other opioids for acute postoperative pain management in adults.
Applying AI to Structured Real-World Data for Pharmacovigilance Purposes: Scoping Review.
J Med Internet Res
December 2024
Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé - LIMICS, Inserm, Université Sorbonne Paris-Nord, Sorbonne Université, Paris, France.
Background: Artificial intelligence (AI) applied to real-world data (RWD; eg, electronic health care records) has been identified as a potentially promising technical paradigm for the pharmacovigilance field. There are several instances of AI approaches applied to RWD; however, most studies focus on unstructured RWD (conducting natural language processing on various data sources, eg, clinical notes, social media, and blogs). Hence, it is essential to investigate how AI is currently applied to structured RWD in pharmacovigilance and how new approaches could enrich the existing methodology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!