A combined SPS-LCD sensor for screening protease specificity.

Chem Commun (Camb)

Manchester Interdisciplinary Biocentre (MIB) and School of Materials, University of Manchester, Grosvenor Street, Manchester, UK M1 7HS.

Published: July 2008

A hydrogel-based sensor for screening protease specificity has been developed that combines the versatility of solid-phase synthesis (SPS) with the simplicity of liquid crystal display (LCD) technology.

Download full-text PDF

Source
http://dx.doi.org/10.1039/b805321aDOI Listing

Publication Analysis

Top Keywords

sensor screening
8
screening protease
8
protease specificity
8
combined sps-lcd
4
sps-lcd sensor
4
specificity hydrogel-based
4
hydrogel-based sensor
4
specificity developed
4
developed combines
4
combines versatility
4

Similar Publications

Hyperspectral Imaging for High Throughput Optical Spectroscopy of pL Droplets.

Anal Chem

January 2025

Nanophotonic Systems Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland.

Droplet-based microfluidics is a powerful tool for high-throughput analysis of liquid samples with significant applications in biomedicine and biochemistry. Nevertheless, extracting content-rich information from single picolitre-sized droplets at high throughputs remains challenging due to the weak signals associated with these small volumes. Overcoming this limitation would be transformative for fields that rely on high-throughput screening, enabling broader multiparametric analysis.

View Article and Find Full Text PDF

In the modern age, half of the population is facing various chronic illnesses due to glucose maintenance in the body, major causes of fatality and inefficiency. The early identification of glucose plays a crucial role in medical treatment and the food industry, particularly in diabetes diagnosis. In the past few years, non-enzymatic electrochemical glucose sensors have received a lot of interest for their ability to identify glucose levels accurately.

View Article and Find Full Text PDF

Brain-Computer Interface and Electrochemical Sensor Based on Boron-Nitrogen Co-Doped Graphene-Diamond Microelectrode for EEG and Dopamine Detection.

ACS Sens

January 2025

Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China.

The simultaneous detection of electroencephalography (EEG) signals and neurotransmitter levels plays an important role as biomarkers for the assessment and monitoring of emotions and cognition. This paper describes the development of boron and nitrogen codoped graphene-diamond (BNGrD) microelectrodes with a diameter of only 200 μm for sensing EEG signals and dopamine (DA) levels, which have been developed for the first time. The optimized BNGrD microelectrode responded sensitively to both EEG and DA signals, with a signal-to-noise ratio of 9 dB for spontaneous EEG signals and a limit of detection as low as 124 nM for DA.

View Article and Find Full Text PDF

The detection of cysteine (Cys) and homocysteine (Hcy) in biological fluids has great significance for early diagnosis, including Alzheimer's and Parkinson's disease. The simultaneous determination of Cys and Hcy with a single probe is still a huge challenge. To enlarge the differences in space structure (line and ring) and energy (-721.

View Article and Find Full Text PDF

Controlled synthesis of faceted nanoparticles on surfaces without explicit use of ligands has gained attention due to their promising applications in electrocatalysis and chemical sensing. Electrodeposition is a desirable method; however, precise control over their size, spatial distribution, and morphology requires extensive optimization. Here, we report the spatially resolved synthesis of shape-controlled Pt nanoparticles and fast screening of synthesis conditions in scanning electrochemical cell microscopy (SECCM) with pulse potentials.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!