The purpose was to examine sighs and spontaneous pauses in regard to the stability of resting breathing in the B6 strain, compared to the A/J strain. A 5-HT1A receptor agonist (buspirone) and a chromosomal substitution strain (B6a1) were used to further alter breathing patterning. Ten-minute recordings of room air breathing were collected from unanaesthetized B6, A/J, and B6a1 mice. Despite no differences between strains in the magnitude and incidence of sighs, post-sigh apneas, the variation for duration of expiration (Te) after sighs, and the number of spontaneous pauses were greater in the B6, while Shannon Entropy (nonlinear metrics) for Te after sighs was lower in B6, compared to the other strains. Buspirone and chromosomal substitution eliminated post-sigh apneas and decreased spontaneous pauses. A greater irregularity and the lower complexity of post-sigh breathing in B6 are reversed by elements on A/J chromosome 1 and by increased 5-HT1A serotonergic tone.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698969 | PMC |
| http://dx.doi.org/10.1016/j.resp.2008.05.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Automated analysis of spoken language differentiates multiple system atrophy from Parkinson's disease.
J Neurol
January 2025
Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Technická 2, Praha 6, 16000, Prague, Czech Republic.
Background And Objectives: Patients with synucleinopathies such as multiple system atrophy (MSA) and Parkinson's disease (PD) frequently display speech and language abnormalities. We explore the diagnostic potential of automated linguistic analysis of natural spontaneous speech to differentiate MSA and PD.
Methods: Spontaneous speech of 39 participants with MSA compared to 39 drug-naive PD and 39 healthy controls matched for age and sex was transcribed and linguistically annotated using automatic speech recognition and natural language processing.
A hands-free carotid Doppler can identify spontaneous circulation without interrupting cardiopulmonary resuscitation: an animal study.
Intensive Care Med Exp
December 2024
Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.
Background: Identifying spontaneous circulation during cardiopulmonary resuscitation (CPR) is challenging. Current methods, which involve intermittent and time-consuming pulse checks, necessitate pauses in chest compressions. This issue is problematic in both in-hospital cardiac arrest and out-of-hospital cardiac arrest situations, where resources for identifying circulation during CPR may be limited.
View Article and Find Full Text PDFFrom "invisible" to "audible": Features extracted during simple speech tasks classify patient-reported fatigue in multiple sclerosis.
Mult Scler
December 2024
UCSF Weill Institute for Neurosciences, San Francisco, CA, USA.
Background: Fatigue is a major "invisible" symptom in people with multiple sclerosis (PwMS), which may affect speech. Automated speech analysis is an objective, rapid tool to capture digital speech biomarkers linked to functional outcomes.
Objective: To use automated speech analysis to assess multiple sclerosis (MS) fatigue metrics.
Pauses in the Dynamics of Handwriting Production: Evidence of Persistent Difficulties in French Students With Dyslexia.
Dyslexia
February 2025
Laboratoire CNRS ICAR, UMR 5191, CNRS, Université Lyon 2 et ENS de Lyon.
Despite the persistent difficulties of people with dyslexia concerning writing, few studies examine the impact of dyslexia on the dynamic aspects of written text production. Our objective is to examine the written productions of students with dyslexia (N = 21), compared with matched control students (N = 22), taking into consideration online indicators. They were asked to produce spontaneous narrative and expository texts.
View Article and Find Full Text PDFNeuronal activity features of the subthalamic nucleus associated with optimal deep brain stimulation electrode insertion path in Parkinson's disease.
Eur J Neurosci
December 2024
Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a standard treatment for advanced Parkinson's disease (PD). The precise positioning of the electrode can significantly influence the results of DBS and the overall improvement in the quality of life for PD patients receiving this therapy. We hypothesize that single unit activity (SUA) features can serve as a valid marker of the optimal DBS-electrode insertion trajectory, leading to the most favorable outcome of STN-DBS surgery.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!