Today several monoclonal antibodies, including the anti-CD20 antibody (rituximab), the anti-CD52 antibody (alemtuzumab) and the anti-CD33 antibody (gemtuzumab ozogamacin) are all integrated in the therapeutic armamentarium of patients with malignant lymphoma, chronic lymphocytic leukaemia and acute myelogenous leukaemia, respectively. Rituximab has also been shown to be highly effective in the treatment of refractory autoimmune haemolytic anemias, idiopathic thrombocytopenia, and relapsing thrombotic thrombocytopenic purpura. New signal transduction inhibitors, dasatinib and nilotinib, are being used in patients with chronic myelogeneous leukaemia who develop resistance to imatinib. Thalidomide, lenalidomide and bortezomib have all been shown to be highly effective in multiple myeloma, and JAK2-inhibitors have entered phase II studies of patients with JAK2-positive primary myelofibrosis and related diseases.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Electrochemical biosensing in oncology: a review advancements and prospects for cancer diagnosis.
Cancer Biol Ther
December 2025
Department of Surgery, Hamad Medical Corporation, Doha, Qatar.
Early and precise diagnosis of cancer is pivotal for effective therapeutic intervention. Traditional diagnostic methods, despite their reliability, often face limitations such as invasiveness, high costs, labor-intensive procedures, extended processing times, and reduced sensitivity for early-stage detection. Electrochemical biosensing is a revolutionary method that provides rapid, cost-effective, and highly sensitive detection of cancer biomarkers.
View Article and Find Full Text PDFMedication experiences in the treatment of opioid use disorders: Insights from Reddit.
Addiction
March 2025
Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, CA, USA.
Background And Aims: Better understanding the challenges faced by patients on medications for opioid use disorder (MOUD), including methadone and buprenorphine, is critical to increasing their use/retention. Social media platforms such as Reddit offer a space for patients to share their experiences with medications. We aimed to identify and characterize challenges faced by patients taking MOUD through analysis of discussions from the r/Methadone and r/suboxone subreddits.
View Article and Find Full Text PDFPhotocatalyzed Aerobic Oxidation of Thiols to Disulfides Using CuO Polyhedra.
ACS Appl Mater Interfaces
March 2025
Department of Chemistry, National Tsing Hua University, Hsinchu 300044, Taiwan.
To further demonstrate semiconductor facet effect to photocatalytic organic transformations and address a lack of using simple polyhedral semiconductor particles for disulfide bond formation, CuO cubes, octahedra, and rhombic dodecahedra were used to photocatalyze aerobic oxidation of 4-methylbenzenethiol. After reaction condition optimization, CuO crystals and ,,','-tetramethylethylenediamine (TMEDA) were added to 4-methylbenzenethiol in ethanol for thiol oxidation to 1,2-di--tolyldisulfane under 390 nm light-emitting diode (LED) lamp irradiation for just 5 min. Rhombic dodecahedra gave the highest product yield, followed by octahedra, cubes, and commercial CuO powder.
View Article and Find Full Text PDFFlexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration.
Adv Mater
March 2025
College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.
The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically.
View Article and Find Full Text PDFNanofibrous Hydrogel with Highly Salt-Resistant Radial/Vertical-Combined Structure for Efficient Solar Interfacial Evaporation.
Small
March 2025
College of Textile and Clothing Engineering, National Engineering Laboratory for Modern Silk, Soochow University, Suzhou, 215021, P. R. China.
Hydrogel-based solar interfacial evaporators, featuring various channels such as random, unidirectional, and radial array, are considered effective for seawater desalination owing to their porous structure, lower evaporation enthalpy, and controllable water transport capacity. However, each individual array structure has its own strengths and limitations, influencing water transportation, thermal management, and salt rejection. By combining the benefits of each array configuration into a single evaporator, the evaporation performance can be maximized.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!