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Bulky malignant peripheral nerve sheath tumour of the left thigh in a pregnant woman presenting with a pathological fracture of the proximal femur.
BMJ Case Rep
April 2024
Department of Orthopedic Surgery, Centro Hospitalar Universitario de Santo António, Porto, Portugal
Malignant peripheral nerve sheath tumour (MPNST) is an aggressive soft tissue sarcoma with a poor prognosis, affecting most commonly the extremities. The lungs constitute the most frequent location for distant metastases. Half of all MPNSTs arise in patients with neurofibromatosis type 1, while approximately 10% are radiation induced and the rest are sporadic.
View Article and Find Full Text PDFA retrospective study on subcutaneous malignant peripheral nerve sheath tumors in 14 domestic rabbits (Oryctolagus cuniculus) treated surgically between 2008 and 2021.
J Vet Med Sci
January 2024
VISION VETS GROUP Lab, Animal Medical Center Peco, Tokyo, Japan.
A retrospective study involving 14 pet rabbits histopathologically diagnosed with malignant peripheral nerve sheath tumors (MPNSTs) was conducted. The age at diagnosis was 4-12 years, with a median age of 8.6 years.
View Article and Find Full Text PDFPrimary de novo malignant peripheral nerve sheath tumor of the breast mimicking mastitis. Report of a case and review of the literature.
Rom J Morphol Embryol
May 2023
Pathology Unit, Department of Medical and Surgical Sciences, University of Cantabria, Santander, Spain;
Malignant peripheral nerve sheath tumor (MPNST) is a rare tumor representing <0.1% of malignant breast tumors. Here, we report a case of sporadic MPNST of the breast in a 45-year-old woman with a fast-evolving painful mass in the right breast associated with edema, redness, and increased local temperature, simulating mastitis.
View Article and Find Full Text PDFA rare case of pulmonary malignant peripheral nerve sheath tumor.
Pulmonology
November 2023
Department of Pulmology, Centro Hospitalar Universitário são João, Portugal.
PRC2 loss drives MPNST metastasis and matrix remodeling.
JCI Insight
October 2022
Department of Internal Medicine.
The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent loss-of-function mutations in PRC2 that are associated with poor outcome. Here, we identify a critical role for PRC2 loss in driving MPNST metastasis.
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