AI Article Synopsis
- The study aimed to assess the prevalence of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV-1) in subgingival plaque of patients with aggressive periodontitis (AgP) and their correlation with periodontal bacteria and clinical parameters.
- Among 120 collected subgingival plaque samples, HCMV was found significantly more in AgP patients (43.8%) compared to healthy subjects (12.9%), and higher rates of HCMV and EBV-1 were observed in patients with more types of pathogenic bacteria detected.
- The findings suggest that HCMV and EBV-1 are more prevalent in AgP patients, indicating a possible synergistic interaction
Article Abstract
Objective: To evaluate the prevalence rates of human cytomegalovirus(HCMV) and Epstein-Barr virus-1(EBV-1) in subgingival plaque and analyze the relationship between herpesviruses, periodontal pathogenic bacteria and periodontal clinical parameters in Chinese patients with aggressive periodontitis(AgP).
Methods: A total of one hundred and twenty subgingival plaque samples were collected from 89 AgP patients and 31 healthy subjects. HCMV and EBV-1 were detected using nested polymerase chain reaction(PCR).Contemporaneously, 8 periodontal pathogenic bacteria including Actinobacillus actinomycetemcomitans(Aa), Porphyromonas gingivalis(Pg), Tannerella forsythensis(Tf), Prevotella intermedia(Pi), Campylobacter rectus(Cr),Fusobacterium nucleatum(Fn), Treponema denticola(Td), Prevotella nigrescens(Pn) were detected by 16S rRNA based PCR.
Results: HCMV was more frequently detected in AgP patients (43.8%) than in healthy controls (12.9%, P<0.01). The prevalence rates of HCMV and EBV-1 in AgP patients with 6-8 kinds of bacteria detected were 54.4% and 17.4%, respectively, significantly higher than those with 3-5 kinds of bacteria detected (P<0.05).
Conclusion: The prevalence rates of HCMV and EBV was higher in AgP patients than in healthy controls. Herpesviruses and periodontal pathogenic bacteria may cooperate synergistically in the development of AgP, which could be considered as a pathogenetic consortium in future investigation of periodontaltitis.
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