Objective: To investigate the existence condition of hepatitis B surface antigen(HBsAg) termination codon bias.
Methods: A total of 174 reference sequences of all kinds of Hepatitis B virus(HBV) genotypes were chosen from GenBank, and compared by BioEdit. Then secondary structure of RNA was constructed and analyzed together.
Results: (1) There were two types of HBsAg termination codon: TAA and TGA in 174 reference sequences. TAA was in 124 cases (71.26%); and TGA in 50 cases (28.74%). (2) There was codon bias selection in HBsAg termination codon, and it could affect the secondary structure of RNA and amino acid sequence encoding protein.
Conclusion: HBsAg termination codon bias exists and may be related to RNA structure and the conservation of protein function in the evolutionary progress.
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