The losses and redistribution of vitamin C in blood fractions (stabilized with reduced glutathione) during 4 hours of storage at room temperature in the dark was studied among 27 elderly women. Storage did not have a statistically significant (p greater than 0.05) effect on the mean vitamin C levels in cells, plasma and whole blood. The results point to a redistribution of vitamin C among blood fractions. It is concluded that vitamin C concentrations in cells rather than in plasma should be the principal indicator of the vitamin C status when blood (stabilized with reduced glutathione) is stored at room temperature before specimen handling.
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Sci Rep
January 2025
Department of Zoology, Faculty of Science, Cairo University, Giza, Egypt.
Plastic pollution and global warming are widespread issues that lead to several impacts on aquatic organisms. Despite harmful studies on both subjects, there are few studies on how temperature increases plastics' adverse effects on aquatic animals, mainly freshwater species. So, this study aims to clarify the potential impact of temperature increases on the toxicological properties of polyvinyl chloride nano-plastics (PVC-NPs) in Nile tilapia (Oreochromis niloticus) by measuring biochemical and oxidative biomarkers.
View Article and Find Full Text PDFBiochimie
January 2025
Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Graduate Program in Biochemistry and Bioprospecting (PPGBBio), Chemical, Pharmaceutical, and Food Sciences Center (CCQFA), Federal University of Pelotas (UFPel), 96010-900 RS, Brazil. Electronic address:
Oxidative stress arises from an imbalance between reactive species (RS) production and the antioxidant defense, increasing the brain susceptibility to neurodegenerative and psychiatric diseases. Besides, changes in the expression or activity of neurotransmitter metabolism enzymes, such as monoamine oxidases (MAO), are also associated with mental disorders, including depression. Considering this, antioxidant and MAO-A activity inhibitory potential of six 2,3-chalcogenodihydrobenzofurans (2,3-DHBF) was investigated through in vitro and in silico tests.
View Article and Find Full Text PDFJ Pharm Biomed Anal
January 2025
Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 48, Münster 48149, Germany. Electronic address:
Minocycline is an antibiotic of the tetracycline family which is widely used to treat a range of medical conditions. Although it has been in use for more than 50 years, little information is available on its metabolism in the human body. In this study, we simulate the biotransformation of minocycline by means of electrochemistry coupled to mass spectrometry.
View Article and Find Full Text PDFTalanta
January 2025
International Ph. D Program in Innovative Technology of Biomedical Engineering & Medical Devices, Ming Chi University of Technology, New Taipei City 243303, Taiwan; Research Center for Intelligence Medical Devices, Ming Chi University of Technology, New Taipei City 243303, Taiwan. Electronic address:
Nanocomposites that mimic the characteristics of enzymes, commonly as nanozymes, can function as an efficient sensing material with high selectivity towards the targeted biological macromolecule. These nanozymes overcome of the challenges that arise when using natural enzymes as sensing material. This study presents a novel nanozyme, Copper Selenite (CuSeO) nanoparticles mounted on f-CNF, to electrochemically determine a potential cardiovascular biomarker, Glutathione (GSH).
View Article and Find Full Text PDFFood Chem
January 2025
College of Food Science and Technology, Northwest University, Xi'an 710069, Shaanxi, China; Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Xi'an 710069, Shaanxi, China; Research Center of Food Safety Risk Assessment and Control, Xi'an 710069, Shaanxi, China. Electronic address:
Apple polyphenols (APP) can reduce obesity. However, the effects of APP on abdominal subcutaneous adipose tissue (aSAT) at metabolic level were unclear. In this study, 5-week APP intervenes were conducted on 10-week high-fat diet (HFD) feeding mice with doses of 200 and 500 mg/kg b.
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