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Anchorage Accurately Assembles Anchor-Flanked Synthetic Long Reads.
Lebniz Int Proc Inform
August 2024
Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA Department of Computer Science and Engineering, The Pennsylvania State University, University Park, PA, USA.
Modern sequencing technologies allow for the addition of short-sequence tags, known as anchors, to both ends of a captured molecule. Anchors are useful in assembling the full-length sequence of a captured molecule as they can be used to accurately determine the endpoints. One representative of such anchor-enabled technology is LoopSeq Solo, a synthetic long read (SLR) sequencing protocol.
View Article and Find Full Text PDFUnlabelled: The reflexive translation of symbols in one chemical language to another defined genetics. Yet, the co-linearity of codons and amino acids is so commonplace an idea that few even ask how it arose. Readout is done by two distinct sets of proteins, called aminoacyl-tRNA synthetases (AARS).
View Article and Find Full Text PDFThe influence of electronic health record design on usability and medication safety: systematic review.
BMC Health Serv Res
January 2025
School of Pharmacy and Biomolecular Sciences (PBS), Royal College of Surgeons in Ireland (RCSI), 1st Floor Ardilaun House Block B, 111 St Stephen's Green, Dublin 2, Ireland.
Background: The advantages of electronic health records (EHRs) are well-documented regarding the process of care, enhanced data accessibility and cost savings. However, EHR design can also contribute to usability challenges, with poorly designed EHRs being implicated in user errors including patient overdoses. Our study seeks to evaluate how EHR design influences both usability and medication safety.
View Article and Find Full Text PDFBiomechanical Analysis and Solution Suggestions of Screw Replacement Scenarios in Femoral Neck Fracture Surgeries: Finite Element Method.
Orthop Surg
January 2025
Department of Orthopaedic and Traumatology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
Objective: Despite several surgical options, there has yet to be a consensus on the best treatment for femoral neck fracture (FNF) due to higher complication rates compared to other bone fractures. This study aims to examine the possible consequences and solution suggestions of changing screws during surgery for various reasons in FNF surgical treatment from a biomechanical perspective.
Method: FNF and treatment materials were analyzed biomechanically using a package program based on the finite element method (FEM).
Mucin5AC promotes breast cancer brain metastasis through cMET/CD44v6.
Clin Cancer Res
January 2025
University of Nebraska Medical Center, OMAHA, NE, United States.
Purpose: Breast cancer (BC) brain metastasis (BrM) remains a significant clinical problem. Mucins have been implicated in metastasis; however, if they are also involved in BCBrM remains unknown. We queried BrM patient databases and found Mucin 5AC (MUC5AC) to be upregulated and therefore sought to define the role of MUC5AC in BCBrM.
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