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http://dx.doi.org/10.3324/haematol.12473 | DOI Listing |
Intern Emerg Med
October 2013
Dipartimento di Medicina Interna e Specialistica, Università di Catania, Catania, Italy,
Patients with chronic obstructive pulmonary disease (COPD) are prone to clinical exacerbations that are associated with increased airway inflammation, a potent pro-thrombotic stimulus. Limited information is available on the mechanisms underlying the putative alterations of the endothelial-coagulative system during acute exacerbations. The aim was to investigate whether the activation of the endothelial-coagulative system occurs in association with the acute inflammatory response of COPD exacerbation.
View Article and Find Full Text PDFEur J Clin Invest
June 2011
Centro per la Prevenzione e Cura del Tabagismo, Azienda Ospedaliero-Universitaria O.V.E., Università di Catania, Catania, Italy.
Background: Cigarette smoking is associated with cardiovascular morbidity and mortality. Exposure to cigarette smoke can cause endothelial dysfunction with impaired endothelium-dependent vasodilation and 'endothelial activation', which predispose to atherothrombosis. The effects of continued smoking and smoking cessation on the level of endothelial, platelet and clotting activation have not been described previously.
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