AI Article Synopsis

  • The paraventricular nucleus (PVN) contains various neuron subgroups, including those with 5-HT(1A) receptors that play a role in regulating hormones like oxytocin (OT), which affects water balance.
  • A study showed that activating these 5-HT(1A) receptors in the PVN led to reduced water intake and increased urine output in rats after 24 hours of being water-deprived.
  • The research indicates that the inhibitory effects on water consumption and the increases in urine formation in dehydrated rats are mediated by the action of serotonergic 5-HT(1A) receptors in a specific area of the PVN.

Article Abstract

The paraventricular nucleus (PVN) may be considered as a dynamic mosaic of chemically-specified subgroups of neurons. 5-HT(1A) is one of the prime receptors identified and there is expressed throughout all magnocellular regions of the PVN. Several reports have demonstrated that a subpopulation of the magnocellular neurons expressing 5-HT(1A) receptors are oxytocin (OT) neurons and activation of 5-HT(1A) receptors in the PVN increases the plasma OT. Increasing evidence shows that OT inhibits water intake and increases urinary excretion in rats. The aim of this study was to investigate the role of serotonergic 5-HT(1A) receptors in the lateral-medial posterior magnocellular region of the PVN in the water intake and diuresis induced by 24 h of water deprivation. Cannulae were implanted in the PVN of rats. 5-HT injections in the PVN reduced water intake and increased urinary excretion. 8-OH-DPAT (a 5-HT(1A) agonist) injections blocked the water intake and increased urinary output in all the periods of the observation. pMPPF (a 5-HT(1A) antagonist) injected bilaterally before the 8-OH-DPAT blocked its inhibitory effect on water intake and its diuretic effect. We suggest that antidipsogenic and diuretic responses seem to be mediated via 5-HT(1A) receptors of the lateral-medial posterior magnocellular region of the PVN in water-deprived rats.

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Source
http://dx.doi.org/10.1016/j.regpep.2008.05.003DOI Listing

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