AI Article Synopsis
- The study presents three cases of men who experienced azoospermia (absence of sperm) after taking clomiphene citrate (CC) for previously diagnosed oligospermia (low sperm count).
- The patients initially had low sperm concentrations and showed no sperm in their semen analyses following CC treatment.
- After discontinuing CC for three months, their sperm concentration improved slightly but remained below normal levels, highlighting the potential risks of using CC.
Article Abstract
Objective: To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake.
Design: Case report.
Setting(s): Academic medical center.
Patient(s): Three patients with oligospermia.
Intervention(s): Three oligospermic men used CC, resulting in azoospermia.
Main Outcome Measure(s): Semen analysis after CC use and after discontinuation of CC.
Result(s): Three patients were sent to our clinic for investigation of their azoospermia after use of CC. They had severe oligozoospermia (sperm concentrations of 3.4, 2.8, and 4.1 x 10(6)/mL, respectively) before treatment with CC. These patients were re-evaluated with two new semen analyses, showing azoospermia. After 3 months without use of the drug, the mean sperm concentration was 2.5 +/- 1.1 x 10(6)/mL.
Conclusion(s): The benefits of empiric treatment with CC must be balanced with the possible undesirable effects, such as azoospermia.
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| http://dx.doi.org/10.1016/j.fertnstert.2008.03.036 | DOI Listing |
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