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Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials.
Crit Care
November 2024
Department of Anaesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, University Hospital of Bielefeld, Campus Bielefeld-Bethel, University of Bielefeld, Burgsteig 13, Haus Gilead I, 33617, Bielefeld, Germany.
Background: Treatment with short-acting betablockers in septic patients remains controversial. Two recent large multicenter trials have provided additional evidence on this therapeutic approach. We thus performed a meta-analysis, including the most recent data, to evaluate the potential impacts of treatment with short-acting betablockers on mortality in adult septic patients.
View Article and Find Full Text PDFDifferential Effects of Landiolol in Patients with Atrial Fibrillation and Atrial Tachycardia.
Medicina (Kaunas)
October 2024
Cardiovascular Center, Miyazaki Medical Association Hospital, Miyazaki 880-2102, Japan.
Landiolol, an ultra-short-acting β1-selective blocker, is more effective in controlling heart rate compared with digoxin in patients with atrial tachyarrhythmias and left ventricular dysfunction. However, the effect of atrial tachyarrhythmia type on the effectiveness of landiolol remains unknown. Hence, this study aimed to evaluate the effectiveness of landiolol in patients with atrial fibrillation (AF) and atrial tachycardia (AT), not limited to those with heart failure with a reduced ejection fraction.
View Article and Find Full Text PDFPropranolol and landiolol inhibit cell proliferation enhanced by noradrenaline in human lung adenocarcinoma cells.
Biomed Res
November 2024
Department of Anesthesiology and Pain Medicine, Graduate School of Medicine, Nippon Medical School.
Previous clinical data have shown that perioperative β-blocker administration can improve lung cancer prognosis, possibly by blocking autonomic nervous system responses. This study aimed to investigate the anticancer mechanisms of the β-blockers propranolol and landiolol for human lung adenocarcinoma cells treated with noradrenaline. A549 human lung adenocarcinoma cells were exposed to each of the following alone or in combination for 2 h: medium only for naïve control; noradrenaline at a dose of 10 μmol/L; propranolol at 10 nmol/L; and landiolol at 1000 nmol/L.
View Article and Find Full Text PDFIdentification of Potential Tryptase Inhibitors from FDA-Approved Drugs Using Machine Learning, Molecular Docking, and Experimental Validation.
ACS Omega
September 2024
Department of Pharmacology, Kangwon National University School of Medicine, Chuncheon, 24341, Republic of Korea.
Article Synopsis
- * The selected compounds underwent molecular docking to evaluate their binding to tryptase and were experimentally tested in rat basophilic leukemia cells to measure their efficacy in inhibiting tryptase and related activities.
- * Results indicated that certain FDA-approved drugs, such as landiolol and cidofovir, effectively inhibited tryptase, showcasing machine learning's potential in drug repurposing and aiding the development of treatments for related diseases.
Landiolol for heart rate control in patients with septic shock and persistent tachycardia. A multicenter randomized clinical trial (Landi-SEP).
Intensive Care Med
October 2024
Department of Anaesthesia and Intensive Care, Charles University, 3rd Medical Faculty and University Hospital Královské Vinohrady, Prague, Czech Republic.
Article Synopsis
- Excessive heart rates in septic shock patients can negatively impact their health, prompting a study on the use of the ultra-short-acting beta-blocker landiolol to control heart rate without raising the need for vasopressors.
- Conducted across 20 sites in Europe from 2018 to 2022, the study compared landiolol combined with standard treatment to standard treatment alone in adults with septic shock and high heart rates, focusing on maintaining a target heart rate (80-94 bpm) without increasing vasopressor requirements.
- Results showed that a higher percentage of patients receiving landiolol achieved the target heart rate compared to those receiving standard treatment (39.8% vs. 23.5%), but there were no
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