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Organoids and spheroids: advanced models for liver cancer research.
Front Cell Dev Biol
January 2025
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Liver cancer is a leading cause of cancer-related deaths worldwide, highlighting the need for innovative approaches to understand its complex biology and develop effective treatments. While traditional animal models have played a vital role in liver cancer research, ethical concerns and the demand for more human-relevant systems have driven the development of advanced models. Spheroids and organoids have emerged as powerful tools due to their ability to replicate tumor microenvironment and facilitate preclinical drug development.
View Article and Find Full Text PDFDeveloping and validating the Sierra Leone perinatal psychological distress scale through an emic-etic approach.
J Affect Disord Rep
January 2025
Institute for Global Health and Development, Queen Margaret University, Edinburgh, UK.
Background: Addressing perinatal psychological distress in Sierra Leone faces challenges due to the lack of culturally appropriate assessment tools, despite recent WHO recommendations for screening during the pre- and postpartum periods. While high-income countries use tools like the Edinburgh Postnatal Depression Scale or Patient Health Questionnaire-9 (PHQ-9), their cross-cultural validity and efficacy in developing countries are uncertain. The aim of this study was to address this gap by developing a functional assessment tool, culturally appropriate screening tool for perinatal psychological distress, and validate it with the PHQ-9.
View Article and Find Full Text PDFEvaluating Infertility Through Diagnostic Hysterolaparoscopy: A Prospective Study.
Cureus
December 2024
Obstetrics and Gynaecology, Dr. D Y Patil Medical College, Hospital and Research Centre, Dr. D Y Patil Vidyapeeth (Deemed to be University) Pimpri, Pune, IND.
Background Infertility affects a significant proportion of reproductive-age couples globally, with diverse causes. Diagnostic hystero-laparoscopy (DHL) is emerging as a preferred diagnostic tool for evaluating infertility, combining laparoscopy and hysteroscopy for comprehensive assessment. Objective The primary objective of this prospective study was to evaluate the diagnostic accuracy and clinical utility of DHL in identifying the causes of infertility in women.
View Article and Find Full Text PDFA Prospective, Observational, Open-Label, Non-comparative, Multi-center Study for the Evaluation of Efficacy and Safety of Levonadifloxacin (Intravenous and Oral) in Patients With Community-Acquired Bacterial Pneumonia.
Cureus
December 2024
Respiratory Medicine, Gujarat Medical Education and Research Society of Department of Health and Family Welfare (GMERS) Medical College and General Hospital, Vadodara, IND.
Background Community-acquired bacterial pneumonia (CABP) is associated with a substantial healthcare burden. The emergence of multi-drug resistance in is becoming an increasing concern in the management of CABP. This study aims to evaluate the efficacy and safety of levonadifloxacin in the treatment of CABP, focusing on both oral and intravenous (IV) therapy.
View Article and Find Full Text PDFGuillain Barré Syndrome Mimicking Brain Death: A Case Report.
Cureus
December 2024
Neurocritical Care, Caritas Hospital and Institute of Health Sciences, Kottayam, IND.
Here, we present a case of Guillain-Barré syndrome (GBS) that mimicked brain death. A 66-year-old lady with a medical history of breast cancer (now receiving hormone therapy), hypertension, and hypothyroidism, presented to the emergency department. The patient was admitted to the neuro ICU with absent brainstem and spinal cord responses, concerning for possible brain death.
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