An autoregressive approach for the prediction of water quality trends in systems subject to varying meteorological conditions and short observation periods is discussed. Under these conditions, the dynamics of the system can be reliably forecast, provided their internal processes are understood and characterized independently of the external inputs. A methodology based on stationary and non-stationary autoregressive processes with external inputs (ARX) is proposed to assess and predict trends in hydrosystems which are at risk of contamination by organic and inorganic pollutants, such as pesticides or nutrients. The procedures are exemplified for the transport of atrazine and its main metabolite deethylatrazine in a small agricultural catchment in France. The approach is expected to be of particular value to assess current and future trends in water quality as part of the European Water Framework Directive and Groundwater Directives.
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http://dx.doi.org/10.1016/j.jconhyd.2008.05.001 | DOI Listing |
Nat Rev Mol Cell Biol
January 2025
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Maintaining homeostasis is essential for continued health, and the progressive decay of homeostatic processes is a hallmark of ageing. Daily environmental rhythms threaten homeostasis, and circadian clocks have evolved to execute physiological processes in a manner that anticipates, and thus mitigates, their effects on the organism. Clocks are active in almost all cell types; their rhythmicity and functional output are determined by a combination of tissue-intrinsic and systemic inputs.
View Article and Find Full Text PDFEur Phys J E Soft Matter
January 2025
Institut für Theoretische Physik II: Weiche Materie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225, Düsseldorf, Germany.
Intelligent decisions in response to external informative input can allow organisms to achieve their biological goals while spending very little of their own resources. In this paper, we develop and study a minimal model for a navigational task, performed by an otherwise completely motorless particle that possesses the ability of hitchhiking in a bath of active Brownian particles (ABPs). Hitchhiking refers to identifying and attaching to suitable surrounding bath particles.
View Article and Find Full Text PDFNat Chem Biol
January 2025
College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China.
Synthetic genetic circuits program the cellular input-output relationships to execute customized functions. However, efforts to scale up these circuits have been hampered by the limited number of reliable regulatory mechanisms with high programmability, performance, predictability and orthogonality. Here we report a class of split-intron-enabled trans-splicing riboregulators (SENTRs) based on de novo designed external guide sequences.
View Article and Find Full Text PDFNat Commun
January 2025
Neurobiology Department, School of Biological Sciences, University of California, San Diego, CA, USA.
The hippocampal CA3 subregion is a densely connected recurrent circuit that supports memory by generating and storing sequential neuronal activity patterns that reflect recent experience. While theta phase precession is thought to be critical for generating sequential activity during memory encoding, the circuit mechanisms that support this computation across hippocampal subregions are unknown. By analyzing CA3 network activity in the absence of each of its theta-modulated external excitatory inputs, we show necessary and unique contributions of the dentate gyrus (DG) and the medial entorhinal cortex (MEC) to phase precession.
View Article and Find Full Text PDFDisabil Rehabil
January 2025
Olga Tennison Autism Research Centre, School of Psychology and Public Health, La Trobe University, Melbourne, Australia.
Purpose: Social support is a known facilitator of exercise for people with disability. A qualitative approach was used to understand current social support practices in community gyms for young adults with disability.
Methods: Embedded within a larger project "Getting Young adult Moving - Supporting Participation and Access to Recreation Centres" (GYM-SPARC), semi-structured interviews were completed with 25 gym staff, representing 29 community gym facilities across Victoria, Australia.
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