Objective: To evaluate the relationship between sperm pathology and cancer diagnosis, determine the mortality rate, and evaluate the outcomes of the use of frozen sperm from the sperm bank.
Design: Prospective study.
Setting: University fertility center.
Patient(s): A total of 619 male patients were referred for sperm freezing before gonadotoxic therapy from 1995 to 2006.
Intervention(s): Semen analysis, data verification in the National Oncologic Register, assisted reproduction technologies, and statistical evaluation.
Main Outcome Measure(s): Cancer diagnosis and sperm pathology analysis, survival of patients, and infertility treatment success.
Result(s): Malignant testicular cancer was diagnosed in 43.6% of patients, and malignant neoplasms of the lymphatic and hematopoietic tissues were found in 31.7% of patients. Azoospermia or severe oligospermia (
Conclusion(s): A significant number of patients survived. Intrauterine insemination and ICSI with cryopreserved sperm resulted in deliveries.
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