We have developed the Thermocross, a simple device for rapid assessment of thermal sensitivity, tested it on healthy subjects and diabetic patients and evaluated its use in identifying patients whose sensation loss may expose them to the risk of neuropathic foot injury. Thermal discrimination deteriorated with age (P less than 0.001) in healthy subjects, but all the controls could detect a temperature difference less than or equal to 10 degrees C. In diabetic patients, the deficit in thermal sensation detected by the Thermocross paralleled the decline of nerve conduction. Thermocross thermal sensation was impaired in 87% of 38 ulcerated feet of 26 diabetic patients. We conclude that the Thermocross is a suitable tool for screening for sensation loss and that diabetic patients with impaired thermal sensation are vulnerable to ulceration. The Thermocross could also serve a useful educational purpose, the implications of reduced thermal sensation probably being more meaningful to patients and health care personnel than those of a reduction in the traditionally tested vibration sensation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0168-8227(91)90127-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phototropin 2 mediates daily cold priming to promote light responses in Arabidopsis.
J Exp Bot
January 2025
Center for Bioscience Research and Education, Utsunomiya University, Tochigi 321-8505, Japan.
Organisms adapt to predictable environmental changes via a biological mechanism called priming. Phototropin (phot) is a plant-specific blue light photoreceptor that mediates daily light-induced responses, such as chloroplast relocation, stomatal opening, and phototropism, to optimize photosynthesis. Phot also functions as a thermosensor for chloroplast relocation that may sense daily temperature decreases at night, thereby modulating light-induced responses at dawn; however, this hypothesis has not yet been fully explored.
View Article and Find Full Text PDFSingle and combined effects of environmental heat stress and physical exercise on thermoregulation, executive function, and cerebral oxygenation.
J Therm Biol
January 2025
School of Exercise and Health, Shanghai University of Sport, Shanghai, 200438, China. Electronic address:
This study investigated the single and combined effects of environmental heat stress and physical exercise on executive function (EF) performance, prefrontal cortex oxygenation, thermoregulatory responses and subjective perceptions. Sixteen subjects participated in four experimental sessions: two under moderate environmental conditions (23 °C), with and without physical exercise (R23, E23), and two under hot environmental conditions (35 °C), with and without physical exercise (R35, E35). In each session, participants completed EF tasks before and after 1 h of passive rest or 45 min of moderate-intensity cycling followed by 15 min of rest.
View Article and Find Full Text PDFImpact of single versus dual arterial supply on perfusion and function in finger replantation after complex hand injuries.
Sci Rep
January 2025
Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625, Hannover, Germany.
Finger amputations following complex hand injuries (CHI) pose a significant challenge in hand surgery due to severe tissue trauma and neurovascular damage, necessitating precise arterial repair. While restoring arterial perfusion is critical, it remains unclear whether reconstructing both proper palmar digital arteries is required for optimal outcomes. This study evaluates whether restoring one or both arteries in finger replantation after complex injuries impacts perfusion and overall outcomes.
View Article and Find Full Text PDFPreliminary Study by Differential Scanning Calorimetric Analysis of Red Blood Cells in Peripheral Artery Disease Patients Treated with Cilostazol: Correlation with Improvements in Walking Distance.
Pharmaceuticals (Basel)
January 2025
Department of Vascular Surgery, Medical School, University of Pécs, H-7624 Pécs, Hungary.
: Peripheral artery disease (PAD) is a prevalent vascular condition characterized by arterial narrowing, which impairs blood flow and manifests as intermittent claudication, a pain or cramping sensation induced by physical activity or ambulation. Walking distance is a crucial clinical indicator of peripheral artery disease, and it correlates with the disease severity and risk of mortality. It reflects the severity of the disease, with reduced mobility indicating an increased risk of morbidity.
View Article and Find Full Text PDFA novel approach to completely alleviate peripheral neuropathic pain in human patients: insights from preclinical data.
Front Neuroanat
January 2025
Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Neuropathic pain is a pervasive health concern worldwide, posing significant challenges to both clinicians and neuroscientists. While acute pain serves as a warning signal for potential tissue damage, neuropathic pain represents a chronic pathological condition resulting from injury or disease affecting sensory pathways of the nervous system. Neuropathic pain is characterized by long-lasting ipsilateral hyperalgesia (increased sensitivity to pain), allodynia (pain sensation in response to stimuli that are not normally painful), and spontaneous unprovoked pain.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!