AI Article Synopsis
- Selective bradykinin B1 receptor antagonists may offer new treatment options for pain and inflammation.
- Understanding the structure-activity relationships of a new compound led to the development of effective B1 receptor antagonists.
- These antagonists showed strong occupancy in the central nervous system of specially modified rats.
Article Abstract
Selective bradykinin (BK) B 1 receptor antagonists could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure activity relationships of the structurally novel HTS lead compound 1 provided potent hBK B 1 receptor antagonists with excellent receptor occupancy in the CNS of hBK B 1 transgenic rats.
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| http://dx.doi.org/10.1021/jm800199h | DOI Listing |
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