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A One Stone Three Birds Paradigm of Photon-Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy.
Adv Sci (Weinh)
January 2025
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, South Korea.
Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliable design guidelines. Moreover, it is often overlooked that conventional PDT can exacerbate the development of tumor immunosuppressive microenvironment, which is apparently unfavorable to clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role in cellular homeostasis and its emerging link to pyroptosis have galvanized interest in ER-centric imaging and therapeutics.
View Article and Find Full Text PDFProbing Biomolecular Interactions with Paramagnetic Nuclear Magnetic Resonance Spectroscopy.
Chembiochem
January 2025
Institute for Drug Discovery, University of Leipzig, Brüderstr. 34, 04103, Leipzig, Germany.
Recent advances in computational methods like AlphaFold have transformed structural biology, enabling accurate modeling of protein complexes and driving applications in drug discovery and protein engineering. However, predicting the structure of systems involving weak, transient, or dynamic interactions, or of complexes with disordered regions, remains challenging. Nuclear Magnetic Resonance (NMR) spectroscopy offers atomic-level insights into biomolecular complexes, even in weakly interacting and dynamic systems.
View Article and Find Full Text PDFFusion Partner Facilitates Expression of Cell-Penetrating Peptide L2 in .
Antibiotics (Basel)
December 2024
Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, 12 Zhongguancun Nandajie St., Haidian District, Beijing 100081, China.
Background: L2 is formed by combining the pheromone of () and a cell-penetrating peptide (CPP) with cell-penetrating selectivity. L2 has more significant penetration and better specificity for killing . However, the production of AMPs by chemical synthesis is always a challenge because of the production cost.
View Article and Find Full Text PDFXanthine Nucleosides with Pyrazolo[3,4-]pyrimidine Skeleton: Functionalization with Halogen Atoms, Clickable Side Chains, Pyrene, and iEDDA Cycloadducts, and Impact of Ionic Forms on Photophysical Properties.
J Org Chem
January 2025
Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Heisenbergstrasse 11, 48149 Münster, Germany.
Xanthine nucleosides play a significant role in the expansion of the four-letter genetic code. Herein, 7-functionalized 8-aza-7-deazaxanthine ribo- and 2'-deoxyribonucleosides are described. 2-Amino-6-alkoxy nucleosides were converted to halogenated 8-aza-7-deazaxanthine nucleosides by deamination followed by hydroxy/alkoxy substitution.
View Article and Find Full Text PDFIntegrating Chemoselective Labeling and Laser-Cleavable Mass Tagging for Determination of Sialic Acids in Glycoconjugates.
Anal Chem
January 2025
Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Material Science and Chemical Engineering, Ningbo University, Ningbo 315211, China.
Sialic acids are the terminal units of glycans in glycoproteins or glycolipids. The determination of sialic acids in glycoconjugates is crucial since they regulate essential biological functions and have a significant nutritional value. To achieve a specific and high-throughput in situ determination of sialic acids in glycoconjugates, a laser-desorption/ionization mass spectrometry (LDI-MS)-based strategy is reported by integrating chemoselective labeling and laser-cleavable mass tagging.
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