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Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded. | LitMetric

Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded.

Nat Rev Microbiol

Department of Molecular Medicine, Rochester, MayoClinic, Minnesota 55905, USA.

Published: July 2008

AI Article Synopsis

Article Abstract

Virotherapy is currently undergoing a renaissance, based on our improved understanding of virus biology and genetics and our better knowledge of many different types of cancer. Viruses can be reprogrammed into oncolytic vectors by combining three types of modification: targeting, arming and shielding. Targeting introduces multiple layers of cancer specificity and improves safety and efficacy; arming occurs through the expression of prodrug convertases and cytokines; and coating with polymers and the sequential usage of different envelopes or capsids provides shielding from the host immune response. Virus-based therapeutics are beginning to find their place in cancer clinical practice, in combination with chemotherapy and radiation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947522PMC
http://dx.doi.org/10.1038/nrmicro1927DOI Listing

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