AI Article Synopsis
- Researchers discovered that higher levels of ghrelin, either from injections or calorie restriction, led to reduced anxiety and depression-like behaviors in tests done on rodents.
- Chronic social stress in rodents raised ghrelin levels consistently, while mice lacking the growth hormone secretagogue receptor (Ghsr) experienced worse effects from stress.
- These results suggest that ghrelin plays a protective role against depression-like symptoms caused by long-term stress.
Article Abstract
We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765052 | PMC |
| http://dx.doi.org/10.1038/nn.2139 | DOI Listing |
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