This letter details the attenuation of hERG in a class of Akt inhibitors through heteroatom insertions into aromatic rings. The development of a cell-active dual Akt 1 and 2 inhibitors devoid of hERG activity is discussed using structure-activity relationships.
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| http://dx.doi.org/10.1016/j.bmcl.2008.05.084 | DOI Listing |
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