Integrin engagement costimulates T cell receptor signaling, but the underlying mechanisms are poorly understood. In this issue of Immunity, Nguyen et al. (2008) show that engagement of VLA-4 promotes sustained signaling by altering the dynamics of actin filaments and signaling molecules at the immunological synapse.
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| http://dx.doi.org/10.1016/j.immuni.2008.05.002 | DOI Listing |
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